家兔中枢去甲肾上腺素能神经元及可乐定的心血管作用
Central noradrenergic neurones and the cardiovascular actions of clonidine in the rabbit.
作者信息
Dollery C T, Reid J L
出版信息
Br J Pharmacol. 1973 Feb;47(2):206-16. doi: 10.1111/j.1476-5381.1973.tb08318.x.
Abstract
- Clonidine (1 mug/kg), given by intracisternal injection to anaesthetized rabbits, lowered mean arterial blood pressure by 33 mmHg and heart rate by 32 beats/min.2. In animals pre-treated with 6-hydroxydopamine (6-OHD 500 mug/kg intracisternally) 7-10 days before, intracisternal clonidine (1 mug/kg) reduced mean arterial blood pressure by only 2.5 mmHg and heart rate by 4 beats/minute.3. The hypotensive action of intravenous clonidine was reduced to 49% of control by pre-treatment with intracisternal 6-OHD. In unanaesthetized normal animals intravenous clonidine (30 mug/kg) lowered mean arterial blood pressure by 19.3 mmHg, while after 6-OHD it fell only 9.4 mmHg.4. These studies suggest that the central hypotensive effect of clonidine is dependent on the integrity of central monoaminergic neurones.
摘要
给麻醉的兔子脑池内注射可乐定（1微克/千克），平均动脉血压降低33毫米汞柱，心率降低32次/分钟。
在7 - 10天前经脑池内注射6 - 羟基多巴胺（6 - OHD 500微克/千克）预处理的动物中，脑池内注射可乐定（1微克/千克）使平均动脉血压仅降低2.5毫米汞柱，心率降低4次/分钟。
经脑池内6 - OHD预处理后，静脉注射可乐定的降压作用降至对照的49%。在未麻醉的正常动物中，静脉注射可乐定（30微克/千克）使平均动脉血压降低19.3毫米汞柱，而注射6 - OHD后仅降低9.4毫米汞柱。
这些研究表明，可乐定的中枢降压作用依赖于中枢单胺能神经元的完整性。
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