利用正常大鼠和免疫交感神经切除大鼠评估交感神经系统在实验性高血压中的作用。

The role of the sympathetic nervous system in experimental hypertension and associated changes in aortic sodium and potassium was studied using normal and immunosympathectomized Sprague-Dawley rats.2. A single injection of antiserum to nerve-growth factor to rats at birth produced less intensive destruction of the peripheral sympathetic system than did two injections (one daily for 2 days). The former are referred to as "partial" immunosympathectomized and the latter as "total" immunosympathectomized rats.3. Maintenance of rats on 1% sodium chloride after unilateral nephrectomy and implantation of 40 mg desoxycorticosterone acetate (DOCA) pellets resulted in sustained DOCA-NaCl hypertension in both normal and "partial" immunosympathectomized rats but not in "total" immunosympathectomized rats. Hypertension was associated with an increase in aortic sodium.4. Constriction of one renal artery with contralateral nephrectomy caused sustained hypertension and an increase in aortic sodium in normal and "partial" immunosympathectomized rats. Renal hypertension in "total" immunosympathectomized rats was not sustained.5. It is concluded that a certain minimum control of the cardiovascular system by the sympathetic system is essential for the production of experimental hypertension and associated electrolyte changes.

利用正常和经免疫交感神经切除的斯普拉格-道利大鼠，研究了交感神经系统在实验性高血压及主动脉钠和钾相关变化中的作用。
出生时给大鼠单次注射神经生长因子抗血清，对外周交感神经系统的破坏程度不如两次注射（连续两天每天注射一次）。前者被称为“部分”免疫交感神经切除大鼠，后者被称为“完全”免疫交感神经切除大鼠。
单侧肾切除并植入40毫克醋酸脱氧皮质酮（DOCA）丸剂后，给大鼠喂食1%氯化钠，正常和“部分”免疫交感神经切除大鼠均出现持续性DOCA-氯化钠高血压，而“完全”免疫交感神经切除大鼠未出现。高血压与主动脉钠增加有关。
一侧肾动脉缩窄并对侧肾切除导致正常和“部分”免疫交感神经切除大鼠出现持续性高血压和主动脉钠增加。“完全”免疫交感神经切除大鼠的肾性高血压未持续。
研究得出结论，交感神经系统对心血管系统进行一定程度的最低控制，对于实验性高血压及相关电解质变化的产生至关重要。

An assessment of the role of the sympathetic nervous system in experimental hypertension using normal and immunosympathectomized rats.