与有限DNase消化过程中释放的蛋白质相比，与核小体选择性结合的非组蛋白。

Defer N, Crepin M, Terrioux C, Kruh J, Gros F

Nucleic Acids Res. 1979 Mar;6(3):953-66. doi: 10.1093/nar/6.3.953.

Cultured mammary cells from GR mouse were used to analyse proteins associated with the mononucleosomes and released by a short micrococcal DNase treatment of nuclei. On metrizamide density gradients, mononucleosomes appear to be heterogeneous according to their content of associated non-histone proteins. Proteins associated with the denser fraction (1.22 - 1.24 g/ml) were analysed by two dimensional electrophoresis and compared to the proteins released by DNase I treatment. All the proteins associated with mononucleosomes were also released by DNase I treatment. It could then be assumed that these proteins are associated with the active part of the genome. Additional proteins were released by micrococcal DNase treatment of the nuclei. They could be involved in a higher order organization of chromatin.

来自GR小鼠的培养乳腺细胞用于分析与单核小体相关且通过对细胞核进行短时间微球菌核酸酶处理而释放的蛋白质。在氯化铯密度梯度上，单核小体根据其相关非组蛋白的含量似乎是异质的。通过二维电泳分析与较密部分（1.22 - 1.24 g/ml）相关的蛋白质，并与DNA酶I处理释放的蛋白质进行比较。所有与单核小体相关的蛋白质也通过DNA酶I处理而释放。因此可以假定这些蛋白质与基因组的活性部分相关。通过对细胞核进行微球菌核酸酶处理还释放了其他蛋白质。它们可能参与染色质的高级组织。