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抗体和补体对人癌细胞表面抗原的体内反应证据。

Evidence for in vivo reaction of antibody and complement to surface antigens of human cancer cells.

作者信息

Irie K, Irie R F, Morton D L

出版信息

Science. 1974 Nov 1;186(4162):454-6. doi: 10.1126/science.186.4162.454.

DOI:10.1126/science.186.4162.454
PMID:4413334
Abstract

The immune adherence test was used to determine whether antibody and complement in cancer patients are fixed in vivo to tumor cells. Human erythrocytes adhered in vitro to the surface of human cancer cells obtained from autopsy and biopsy. Adherence was enhanced by further addition of the C2 and C3 components of complement, and was diminished by preliminary treatment with antibody to C3 (that is, to beta1C-globulin). The results suggest that tumor associated membrane antigens form complexes in vivo with antibodies and complement.

摘要

免疫黏附试验用于确定癌症患者体内的抗体和补体是否与肿瘤细胞结合。人红细胞在体外黏附于从尸检和活检获得的人癌细胞表面。补体的C2和C3成分进一步添加可增强黏附，而用抗C3抗体（即抗β1C球蛋白）预处理则会减弱黏附。结果表明，肿瘤相关膜抗原在体内与抗体和补体形成复合物。

相似文献

1
Evidence for in vivo reaction of antibody and complement to surface antigens of human cancer cells.抗体和补体对人癌细胞表面抗原的体内反应证据。
Science. 1974 Nov 1;186(4162):454-6. doi: 10.1126/science.186.4162.454.
2
Anti-tumor activity in human serum: antibodies detecting blood-group-A-like antigen on the surface of tumor cells in culture.人血清中的抗肿瘤活性：检测培养的肿瘤细胞表面血型A样抗原的抗体。
Int J Cancer. 1973 Jul 15;12(1):21-31. doi: 10.1002/ijc.2910120103.
3
Immune adherence reactions of human erythrocytes sensitized with complement in vitro and in vivo.人红细胞在体外和体内经补体致敏后的免疫黏附反应。
J Immunol. 1971 Dec;107(6):1714-22.
4
Activated guinea-pig C3 and the immune adherence receptor (a complement receptor) on cell membranes.活化的豚鼠C3与细胞膜上的免疫黏附受体（一种补体受体）。
Immunology. 1975 Jun;28(6):1165-71.
5
Reduced immune adherence of antigen/antibody complexes formed in the presence of complement in vivo and in vitro.体内和体外在补体存在的情况下形成的抗原/抗体复合物的免疫黏附减少。
Complement Inflamm. 1989;6(6):470-9. doi: 10.1159/000463116.
6
Studies on the in vivo effects of antibody. Interaction of IgM antibody and complement in the immune clearance and destruction of erythrocytes in man.抗体的体内效应研究。人类中IgM抗体与补体在红细胞免疫清除和破坏中的相互作用。
J Clin Invest. 1974 Aug;54(2):339-48. doi: 10.1172/JCI107769.
7
Endogenous immune complex nephropathy associated with malignancy I. Studies on the nature and immunopathogenic significance of glomerular bound antigen and antibody, isolation and characterization of tumor specific antigen and antibody and circulating immune complexes.与恶性肿瘤相关的内源性免疫复合物肾病I. 肾小球结合抗原和抗体的性质及免疫致病意义、肿瘤特异性抗原和抗体的分离与鉴定以及循环免疫复合物的研究
Q J Med. 1975 Oct;44(176):523-41.
8
Detection of antibody and complement complexed in vivo on membranes of human cancer cells by mixed hemadsorption techniques.用混合血细胞吸附技术检测体内与人癌细胞膜结合的抗体和补体复合物。
Cancer Res. 1975 May;35(5):1244-8.
9
The failure to show a necessary role for C3 in the in vitro antibody response.未能证明补体C3在体外抗体反应中发挥必要作用。
Eur J Immunol. 1975 Feb;5(2):185-93. doi: 10.1002/eji.1830050307.
10
C3 split products inhibit the binding of antigen-antibody-complement complexes to B lymphocytes.C3裂解产物可抑制抗原-抗体-补体复合物与B淋巴细胞的结合。
J Immunol. 1973 May;110(5):1452-3.

引用本文的文献

1
Complement in cancer: untangling an intricate relationship.补体系统在癌症中的作用：揭示复杂关系。
Nat Rev Immunol. 2018 Jan;18(1):5-18. doi: 10.1038/nri.2017.97. Epub 2017 Sep 18.
2
Regulation of CR3 (CD11b/CD18)-dependent natural killer (NK) cell cytotoxicity by tumour target cell MHC class I molecules.肿瘤靶细胞MHC I类分子对CR3（CD11b/CD18）依赖性自然杀伤（NK）细胞细胞毒性的调节作用。
Clin Exp Immunol. 1999 Feb;115(2):229-35. doi: 10.1046/j.1365-2249.1999.00800.x.
3
Human carcinomas variably express the complement inhibitory proteins CD46 (membrane cofactor protein), CD55 (decay-accelerating factor), and CD59 (protectin).
人类癌症会不同程度地表达补体抑制蛋白CD46（膜辅因子蛋白）、CD55（衰变加速因子）和CD59（保护素）。
Am J Pathol. 1996 Jul;149(1):129-42.
4
Identification of a human neuroectodermal tumor antigen (OFA-I-2) as ganglioside GD2.鉴定一种人类神经外胚层肿瘤抗原（OFA-I-2）为神经节苷脂GD2。
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7629-33. doi: 10.1073/pnas.79.24.7629.
5
Human antibody to OFA-I, a tumor antigen, produced in vitro by Epstein-Barr virus-transformed human B-lymphoid cell lines.由爱泼斯坦-巴尔病毒转化的人B淋巴细胞系在体外产生的针对肿瘤抗原OFA-I的人抗体。
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5666-70. doi: 10.1073/pnas.79.18.5666.
6
Ganglioside GM2 as a human tumor antigen (OFA-I-1).神经节苷脂GM2作为一种人类肿瘤抗原（OFA-I-1）。
Proc Natl Acad Sci U S A. 1983 Sep;80(17):5392-6. doi: 10.1073/pnas.80.17.5392.
7
Extracorporeal immunoadsorption of circulating specific serum factors in cancer patients.癌症患者循环特异性血清因子的体外免疫吸附
Br J Cancer. 1975 Dec;32(6):680-92. doi: 10.1038/bjc.1975.279.
8
Immune adherence reactivity of rat alveolar macrophages following inhalation of crocidolite asbestos.吸入青石棉后大鼠肺泡巨噬细胞的免疫黏附反应性
Clin Exp Immunol. 1977 Jul;29(1):152-8.
9
Immunoadherence and complement in cancer-bearing mice.荷癌小鼠中的免疫黏附和补体
Br J Cancer. 1978 Jan;37(1):23-7. doi: 10.1038/bjc.1978.3.
10
Clinical relevance of circulating immune complexes in human leukemia. Association in acute leukemia of the presence of immune complexes with unfavorable prognosis.循环免疫复合物在人类白血病中的临床相关性。免疫复合物的存在与急性白血病不良预后的关联。
J Clin Invest. 1977 Oct;60(4):874-84. doi: 10.1172/JCI108842.