Porta C, Villa M L, Clerici E
Br J Cancer. 1978 Jan;37(1):23-7. doi: 10.1038/bjc.1978.3.
Shortly after grafting of Ehrlich ascites carcinoma cells, the serum of tumour-bearing mice loses the capacity to mediate immunoadherence phenomena, because of a sharp decrease in the concentration of C3b and C3d, while the cellular receptors for such factors are unaffected by tumour growth. It is suggested that complement is consumed through the alternative pathway which is activated during the inflammatory responses accompanying tumour growth.
艾氏腹水癌细胞移植后不久，荷瘤小鼠血清介导免疫黏附现象的能力丧失，原因是C3b和C3d浓度急剧下降，而这些因子的细胞受体不受肿瘤生长影响。提示补体通过替代途径被消耗，该途径在肿瘤生长伴随的炎症反应中被激活。
