Holcroft J W, Trunkey D D
Ann Surg. 1974 Oct;180(4):408-17. doi: 10.1097/00000658-197410000-00005.
Baboons were subjected to deep hemorrhagic shock by using a membrane potential of -65 mv as an endpoint. They were then resuscitated with either Plasmanate plus their shed blood or Ringer's lactate plus their shed blood. As compared with their own preshock values, the Plasmanate-resuscitated animals accumulated more extravascular lung water than the Ringer's lactate-resuscitated animals. Another group of baboons resuscitated from deep shock demonstrated significant extravasation of albumin on postmortem analysis of lung composition. This increased tendency for extravasation of albumin after shock partially explains why resuscitation with Plasmanate gave no protection against the formation of pulmonary edema. The authors believe that Plasmanate, and probably other colloidal solutions, should be used sparingly in the initial treatment of deep hemorrhagic shock.
通过将膜电位设定为-65毫伏作为终点，使狒狒遭受深度失血性休克。然后分别用血浆蛋白分离液加自身失血或乳酸林格液加自身失血对它们进行复苏。与休克前自身的值相比，用血浆蛋白分离液复苏的动物比用乳酸林格液复苏的动物积累了更多的血管外肺水。另一组从深度休克中复苏的狒狒在死后肺成分分析中显示白蛋白有明显外渗。休克后白蛋白外渗增加的趋势部分解释了为什么用血浆蛋白分离液复苏不能预防肺水肿的形成。作者认为，在深度失血性休克的初始治疗中，应谨慎使用血浆蛋白分离液以及可能的其他胶体溶液。
