Holcroft J W, Trunkey D D, Carpenter M A
J Trauma. 1977 Aug;17(8):600-10.
Septic shock and the formation of pulmonary edema were studied in 19 baboons. Four animals served as controls. Four were subjected to deep septic shock by infusion of live E. coli and then deliberately killed while in deep shock. Four were subjected to septic shock, resuscitated with Ringer's lactate (RL), and then killed 11/2 hours after resuscitation was started. Seven were subjected to shock and resuscitation attempted with Plasmanate (PL). Resuscitation with RL was successful for 11/2 hours in all four RL-animals. Resuscitation with PL was successful for 11/2 hours in three of the 7 PL-animals. There was an increased tendency for albumin to extravasate into the interstitium of the lungs after resuscitation. The amount of pulmonary edema, measured by both the thermodye technique and by analysis of post-mortem lung composition, was the same in animals resuscitated with RL and PL. Administration of pure colloid offers no protection to the lungs in resuscitating patients from septic shock.
对19只狒狒进行了脓毒性休克和肺水肿形成的研究。4只动物作为对照。4只通过输注活大肠杆菌遭受严重脓毒性休克，然后在深度休克状态下被故意处死。4只遭受脓毒性休克，用乳酸林格液（RL）进行复苏，然后在开始复苏1.5小时后处死。7只遭受休克并尝试用血浆蛋白液（PL）进行复苏。在所有4只用RL复苏的动物中，用RL复苏成功维持了1.5小时。在7只用PL复苏的动物中，3只成功维持了1.5小时。复苏后白蛋白渗入肺间质的趋势增加。通过热染料技术和对死后肺成分分析测量的肺水肿量，在用RL和PL复苏的动物中是相同的。在对脓毒性休克患者进行复苏时，给予纯胶体对肺没有保护作用。
