O'Flaherty J T, Kreutzer D L, Ward P A
Prostaglandins. 1979 Feb;17(2):201-10. doi: 10.1016/0090-6980(79)90039-x.
Recently we have found that chemotactic factors stimulate neutrophils in suspension to aggregate. Because of an obvious analogy to platelet aggregation, we examined the influence of three prostaglandins on this process. Prostaglandins E1, E2 and F2alpha alone did not cause aggregation of the neutrophils but were able to partially inhibit the aggregation response induced by the synthetic chemotactic tripeptide, formyl-methionyl-leucyl-phenylalanine. The minimal inhibitory concentrations for prostaglandins E1, E2 and F2alpha were 10(-7), 10(-6) and 10(-5)M, respectively. These results are similar to those found for the prostaglandin-induced inhibition of platelet aggregation. It may be, therefore, that neutrophil aggregation, like platelet aggregation, is modulated by intracellular prostaglandins and other products of arachidonic acid metabolism.
最近我们发现趋化因子可刺激悬浮状态下的中性粒细胞发生聚集。由于与血小板聚集有明显的相似性，我们研究了三种前列腺素对这一过程的影响。单独的前列腺素E1、E2和F2α不会引起中性粒细胞聚集，但能够部分抑制由合成趋化三肽甲酰甲硫氨酰亮氨酰苯丙氨酸诱导的聚集反应。前列腺素E1、E2和F2α的最小抑制浓度分别为10^(-7)、10^(-6)和10^(-5)M。这些结果与前列腺素诱导的血小板聚集抑制作用的结果相似。因此，中性粒细胞聚集可能像血小板聚集一样，受到细胞内前列腺素和花生四烯酸代谢的其他产物的调节。
