硬化性苔藓患者的器官特异性抗体。
Organ-specific antibodies in patients with lichen sclerosus.
作者信息
Goolamali S K, Barnes E W, Irvine W J, Shuster S
出版信息
Br Med J. 1974 Oct 12;4(5936):78-9. doi: 10.1136/bmj.4.5936.78.
Abstract
Organ-specific antibodies were looked for in 26 patients with lichen sclerosus. Ten of the 25 female patients (40%) had organ-specific antibodies to thyroid cytoplasm and 11 (44%) had organ-specific antibodies to gastric parietal cells. Both values were significantly greater than those obtained in age-matched controls. None of the sera from patients with lichen sclerosus contained antibodies to steroid-producing tissues. No organ-specific antibodies were found in the one male patient.The findings suggest that lichen sclerosus may be related to an autoimmune process.
摘要
对26例硬化性苔藓患者进行了器官特异性抗体检测。25例女性患者中有10例（40%）存在甲状腺细胞质器官特异性抗体，11例（44%）存在胃壁细胞器官特异性抗体。这两个数值均显著高于年龄匹配的对照组。硬化性苔藓患者的血清中均未检测到针对类固醇生成组织的抗体。1例男性患者未发现器官特异性抗体。这些发现提示硬化性苔藓可能与自身免疫过程有关。
相似文献
1
Organ-specific antibodies in patients with lichen sclerosus.硬化性苔藓患者的器官特异性抗体。
Br Med J. 1974 Oct 12;4(5936):78-9. doi: 10.1136/bmj.4.5936.78.
2
Thyroid and gastric autoimmunity in patients with diabetes mellitus.糖尿病患者的甲状腺和胃部自身免疫
Lancet. 1970 Jul 25;2(7665):163-8. doi: 10.1016/s0140-6736(70)92531-6.
3
Autoantibodies in patients with vitiligo.
Lancet. 1969 Jul 26;2(7613):177-8. doi: 10.1016/s0140-6736(69)91421-4.
4
Tissue-specific autoantibodies and autoimmune disorders in vitiligo and alopecia areata: a retrospective study.白癜风和斑秃中的组织特异性自身抗体与自身免疫性疾病：一项回顾性研究。
J Cutan Pathol. 1984 Dec;11(6):522-30. doi: 10.1111/j.1600-0560.1984.tb00413.x.
5
An investigation into the incidence of auto-immune disorders in patients with lichen sclerosus and atrophicus.一项关于硬化萎缩性苔藓患者自身免疫性疾病发病率的调查。
Br J Dermatol. 1981 May;104(5):563-6. doi: 10.1111/j.1365-2133.1981.tb08172.x.
6
Incidence and titers of antinuclear, antismooth muscle, and other autoantibodies in blood donors.献血者血液中抗核抗体、抗平滑肌抗体及其他自身抗体的发生率和滴度
J Lab Clin Med. 1975 Aug;86(2):259-65.
7
The association of lichen sclerosus et atrophicus and autoimmune-related disease in males.男性硬化性萎缩性苔藓与自身免疫相关疾病的关联。
Br J Dermatol. 1983 Dec;109(6):661-4. doi: 10.1111/j.1365-2133.1983.tb00546.x.
8
Organ-specific autoantibodies in coeliac disease: do they represent an epiphenomenon or the expression of associated autoimmune disorders?乳糜泻中的器官特异性自身抗体：它们是一种附带现象还是相关自身免疫性疾病的表现？
Ital J Gastroenterol Hepatol. 1997 Feb;29(1):18-21.
9
Thyroid, gastric and adrenal auto-immunity in diabetes mellitus.
Acta Endocrinol (Copenh). 1973 Feb;72(2):279-86. doi: 10.1530/acta.0.0720279.
10
Organ-specific autoantibodies in vitiligo patients and their relatives.白癜风患者及其亲属体内的器官特异性自身抗体。
Int J Dermatol. 1996 Jan;35(1):18-21. doi: 10.1111/j.1365-4362.1996.tb01609.x.
引用本文的文献
1
The risk of thyroid diseases in lichen sclerosus patients: a systematic review and meta-analysis.硬化性苔藓患者患甲状腺疾病的风险：一项系统评价与荟萃分析。
Ann Med. 2025 Dec;57(1):2548978. doi: 10.1080/07853890.2025.2548978. Epub 2025 Aug 21.
2
A Guide to Screening for Autoimmune Diseases in Patients With Vulvar Lichen Sclerosus.外阴硬化性苔藓患者自身免疫性疾病筛查指南
Australas J Dermatol. 2025 May;66(3):135-141. doi: 10.1111/ajd.14434. Epub 2025 Feb 14.
3
The Potential Coexistence of Autoimmune Thyroid Diseases and Pediatric Vulvar .自身免疫性甲状腺疾病与小儿外阴疾病可能并存
Children (Basel). 2024 Feb 16;11(2):255. doi: 10.3390/children11020255.
4
Lichen Sclerosus: A Current Landscape of Autoimmune and Genetic Interplay.硬化性苔藓：自身免疫与遗传相互作用的现状
Diagnostics (Basel). 2022 Dec 6;12(12):3070. doi: 10.3390/diagnostics12123070.
5
Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets.硬化性苔藓：一种自身免疫性疾病，具有潜在的遗传和免疫靶点。
Int J Biol Sci. 2019 Jun 2;15(7):1429-1439. doi: 10.7150/ijbs.34613. eCollection 2019.
6
Thyroid Autoimmunity and Lichen.甲状腺自身免疫与扁平苔藓。
Front Endocrinol (Lausanne). 2017 Jun 27;8:146. doi: 10.3389/fendo.2017.00146. eCollection 2017.
7
Two distinct pathways to development of squamous cell carcinoma of the vulva.外阴鳞状细胞癌发展的两种不同途径。
J Skin Cancer. 2011;2011:951250. doi: 10.1155/2011/951250. Epub 2010 Sep 28.
8
Vulvar lichen sclerosus in the elderly: pathophysiology and treatment update.老年外阴硬化性苔藓：病理生理学和治疗进展。
Drugs Aging. 2009;26(10):803-12. doi: 10.2165/11316820-000000000-00000.
9
[Vulvar lichen sclerosus. The importance of early clinical and histological diagnosis].[外阴硬化性苔藓。早期临床及组织学诊断的重要性]
Hautarzt. 2004 Feb;55(2):158-64. doi: 10.1007/s00105-003-0645-8.
10
Lichen sclerosus et atrophicus and sexual abuse.硬化萎缩性苔藓与性虐待
Arch Dis Child. 1996 Dec;75(6):512-6. doi: 10.1136/adc.75.6.512.
本文引用的文献
1
Complement-fixing antithyroid antibodies in hospital patients with asymptomatic thyroid lesions.医院中患有无症状甲状腺病变患者的补体结合性抗甲状腺抗体
J Pathol Bacteriol. 1959 Apr;77(2):389-400. doi: 10.1002/path.1700770208.
2
Vitiligo.白癜风
J Invest Dermatol. 1959 Feb;32(2, Part 2):285-310.
3
Addisonian pernicious anaemia and intrinsic factor antibodies in thyroid disorders.甲状腺疾病中的艾迪生病性恶性贫血与内因子抗体
Q J Med. 1966 Jul;35(139):421-31.
4
Vitiligo and its aetiological relationship to organ-specific autoimmune disease.
Br J Dermatol. 1969 Feb;81(2):83-8. doi: 10.1111/j.1365-2133.1969.tb15985.x.
5
Vitiligo, thyroid disease and autoimmunity.白癜风、甲状腺疾病与自身免疫
Br J Dermatol. 1968 Mar;80(3):135-9. doi: 10.1111/j.1365-2133.1968.tb12282.x.
6
Experience with a simplified method of radio-isotopic assay of serum vitamin B 12.
Br J Haematol. 1969 May;16(5):457-64. doi: 10.1111/j.1365-2141.1969.tb00424.x.
7
8
Thyroid and gastric autoimmunity in patients with diabetes mellitus.糖尿病患者的甲状腺和胃部自身免疫
Lancet. 1970 Jul 25;2(7665):163-8. doi: 10.1016/s0140-6736(70)92531-6.
9
Intrinsic-factor antibody, parietal-cell antibody, and latent pernicious anaemia in diabetes mellitus.
Lancet. 1968 Aug 24;2(7565):415-7. doi: 10.1016/s0140-6736(68)90462-5.
10
Association of autoantibodies with smoking, cardiovascular morbidity, and death in the Busselton population.
Lancet. 1973 Oct 6;2(7832):754-8. doi: 10.1016/s0140-6736(73)91037-4.
Zotero 插件