Goolamali S K, Barnes E W, Irvine W J, Shuster S
Br Med J. 1974 Oct 12;4(5936):78-9. doi: 10.1136/bmj.4.5936.78.
Organ-specific antibodies were looked for in 26 patients with lichen sclerosus. Ten of the 25 female patients (40%) had organ-specific antibodies to thyroid cytoplasm and 11 (44%) had organ-specific antibodies to gastric parietal cells. Both values were significantly greater than those obtained in age-matched controls. None of the sera from patients with lichen sclerosus contained antibodies to steroid-producing tissues. No organ-specific antibodies were found in the one male patient.The findings suggest that lichen sclerosus may be related to an autoimmune process.
对26例硬化性苔藓患者进行了器官特异性抗体检测。25例女性患者中有10例（40%）存在甲状腺细胞质器官特异性抗体，11例（44%）存在胃壁细胞器官特异性抗体。这两个数值均显著高于年龄匹配的对照组。硬化性苔藓患者的血清中均未检测到针对类固醇生成组织的抗体。1例男性患者未发现器官特异性抗体。这些发现提示硬化性苔藓可能与自身免疫过程有关。
