Harrington C I, Dunsmore I R
Br J Dermatol. 1981 May;104(5):563-6. doi: 10.1111/j.1365-2133.1981.tb08172.x.
Patients with lichen sclerosus and atrophicus have an increased incidence of organ specific antibodies, and these patients and their relatives have a significantly higher incidence of associated autoimmune diseases than a control population. The incidence of other auto-immune diseases in patients with lichen sclerosus is highest when the onset is between the ages of 41 and 60 years, but is not related to the duration or site of the lesions. These findings suggest an immunological basis for the disease and indicate that the patients should be investigated and followed up to detect the existence of other auto-immune disorders.
患有硬化萎缩性苔藓的患者器官特异性抗体的发生率增加，并且这些患者及其亲属患相关自身免疫性疾病的发生率明显高于对照组人群。硬化萎缩性苔藓患者中其他自身免疫性疾病的发生率在发病年龄介于41至60岁之间时最高，但与病变的持续时间或部位无关。这些发现提示了该疾病的免疫学基础，并表明应对患者进行检查和随访，以检测是否存在其他自身免疫性疾病。
