Irvine W J, Chan M M, Scarth L
Clin Exp Immunol. 1969 May;4(5):489-503.
Antibodies reactive with the steroid-producing cells in the gonads are described in the sera of ten patients, the majority of whom were known to have idiopathic adrenal insufficiency (Addison's disease) associated with premature ovarian failure. The immunofluorescent staining pattern of these antibodies with steroid-producing cells in the ovary, testis, placenta and adrenal cortex are illustrated. The staining patterns and the results of absorption studies indicate that there are a multiplicity of antibodies reacting with different antigens in the ovary and to a lesser extent in the testis. Most of these antigens are also represented in the adrenal cortex, but are not evenly distributed throughout the cortex. Some of these antigens are not represented in the zona glomerulosa while others are not represented in the zona reticularis.
在10名患者的血清中发现了与性腺中产生类固醇的细胞发生反应的抗体，其中大多数患者已知患有特发性肾上腺皮质功能不全（艾迪生病）并伴有卵巢早衰。文中展示了这些抗体与卵巢、睾丸、胎盘和肾上腺皮质中产生类固醇的细胞的免疫荧光染色模式。染色模式和吸收研究结果表明，存在多种与卵巢中不同抗原发生反应的抗体，在睾丸中的反应程度较小。这些抗原中的大多数在肾上腺皮质中也有表现，但在整个皮质中分布不均。其中一些抗原在球状带中没有表现，而另一些在网状带中没有表现。
