Nisticò G, Marmo E
Res Commun Chem Pathol Pharmacol. 1979 Jan;23(1):89-95.
Antagonism of PGE1 and PGE2 fever by catecholamines in adult fowls was studied by infusing these substances into the brain. PGE1 and PGE2, given into the third cerebral ventricle or into the hypothalamus, produced an immediate, intense and long-lasting increase in body temperature. Noradrenaline and alpha-methylnoradrenaline infused into the hypothalamus or into the third cerebral ventricle during the fever peak were able to antagonize it and to revert the hyperthermic effect into an hypothermic effect. The possible modes of action of PG's and relations with catecholaminergic neurons in the hypothalamus are discussed.
通过将这些物质注入成年家禽大脑，研究了儿茶酚胺对PGE1和PGE2发热的拮抗作用。将PGE1和PGE2注入第三脑室或下丘脑后，体温立即出现强烈且持久的升高。在发热高峰期间，将去甲肾上腺素和α-甲基去甲肾上腺素注入下丘脑或第三脑室，能够拮抗发热并将体温升高效应转变为体温降低效应。文中讨论了前列腺素可能的作用方式以及与下丘脑儿茶酚胺能神经元的关系。
