Gurin V N, Vismont F I, Tsariuk V V
Farmakol Toksikol. 1984 Nov-Dec;47(6):29-32.
It has been demonstrated in rat experiments that the central action of PGE2 results in body temperature rise associated with a reduction in the functional activity of hypothalamic adrenergic systems. In contrast to PGE2 and the beta-adrenomimetic isoproterenol, the alpha-adrenomimetics noradrenaline, mezaton and clonidine were shown to lower body temperature. In the rabbit, clonidine and PGE2 were found to have opposing effects on the neuronal activity of the anterior hypothalamus.
大鼠实验已证明，前列腺素E2（PGE2）的中枢作用会导致体温升高，同时下丘脑肾上腺素能系统的功能活动降低。与PGE2和β-肾上腺素能拟似药异丙肾上腺素相反，α-肾上腺素能药去甲肾上腺素、美加明和可乐定可降低体温。在兔子身上，发现可乐定和PGE2对下丘脑前部的神经元活动有相反的作用。
