具有中枢神经系统和抗高血压活性的吡咯并(4,3,2 - de)异喹啉类化合物。 - Suppr

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超能文献

Pyrrolo(4,3,2-de)isoquinolines with central nervous system and antihypertensive activities.

作者信息

Demerson C A, Philipp A H, Humber L G, Kraml M J, Charest M P, Tom H, Vávra I

出版信息

J Med Chem. 1974 Nov;17(11):1140-5. doi: 10.1021/jm00257a003.

DOI:10.1021/jm00257a003

PMID:4415412

Abstract

摘要

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Pyrrolo(4,3,2-de)isoquinolines with central nervous system and antihypertensive activities.具有中枢神经系统和抗高血压活性的吡咯并(4,3,2 - de)异喹啉类化合物。

J Med Chem. 1974 Nov;17(11):1140-5. doi: 10.1021/jm00257a003.

Restoration of tyramine responses by bretylium, BW392C60, bethanidine and monoamine oxidase inhibitors in reserpine-treated rats.在利血平处理的大鼠中，溴苄铵、BW392C60、苄乙胍和单胺氧化酶抑制剂对酪胺反应的恢复作用

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Antihypertensive and monoamine oxidase inhibitory activity of some derivatives of 3-formyl-4-oxo-4H-pyrido (1,2-a) pyrimidine.3-甲酰基-4-氧代-4H-吡啶并[1,2-a]嘧啶某些衍生物的抗高血压和单胺氧化酶抑制活性

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3,4-Dihydroisocarbostyril and 1,2,3,4-tetrahydroisoquinoline derivatives of ephedrine.麻黄碱的3,4-二氢异喹啉酮和1,2,3,4-四氢异喹啉衍生物。

J Med Chem. 1973 Apr;16(4):342-7. doi: 10.1021/jm00262a007.

On the physiological disposition and possible mechanism of the antihypertensive action of debrisoquin.

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Antihypertensive and monoamine oxidase inhibitory activity of 3-amino-2-oxazolidinone (3AO) and its condensation product with 2-substituted-3-formyl-4-oxo-(4H) pyrido(1,2-a)pyrimidines.

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Synthesis and hypotensive properties of tetrahydroisoquinolines.四氢异喹啉的合成及其降压特性

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Selective monoamine oxidase inhibitors. 1. Compounds related to 4-aminophenethylamine.

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The use of intravenous tyramine and the cold pressor test to help elucidate a possible mechanism of action of a new isoquinoline compound shown to have antihypertensive properties in humans.使用静脉注射酪胺和冷加压试验来帮助阐明一种新的异喹啉化合物在人体中显示出降压特性的可能作用机制。

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[Pharmacological and biochemical effects of hydralazine and dihydralazine].

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