Frazer D G, Stengel P W, Weber K C
Respir Physiol. 1979 Feb;36(2):121-9. doi: 10.1016/0034-5687(79)90019-7.
The object of this study was to determine the transpulmonary pressure at which menisci form in the airways of excised rat lungs. The necessary geometric requirements for meniscus formation are normally met in the airways, but a meniscus is presumably prevented from forming at large lung volumes because too little fluid is present. At lower lung volumes a meniscus could form easier since airway caliber is reduced and less fluid is required. A series of pressure-volume curves were recorded for lungs in which meniscus formation was inhibited by increasing the end expiratory pressure. Assuming the number of airways containing at least one meniscus was proportional to the amount of gas trapped in the excised rat lung, it was found that the menisci were formed in 68% of the airways between positive transpulmonary pressures of 1.4 and 3.0 cm H2O during deflation.
本研究的目的是确定在离体大鼠肺气道中形成半月板时的跨肺压。气道通常满足半月板形成所需的几何条件，但在大肺容积时，半月板可能无法形成，因为此时存在的液体过少。在较低肺容积时，由于气道管径减小且所需液体减少，半月板更容易形成。通过增加呼气末压力来抑制半月板形成，记录了一系列肺的压力-容积曲线。假设至少含有一个半月板的气道数量与离体大鼠肺中滞留的气体量成正比，发现在放气过程中，跨肺压为1.4至3.0 cm H2O时，68%的气道中形成了半月板。
