Ward S A, Drysdale D B, Cunningham D J, Petersen E S
Respir Physiol. 1979 Apr;36(3):311-25. doi: 10.1016/0034-5687(79)90044-6.
Breath-by-breath respiratory responses of three healthy adults to imposed alternate-breath oscillation of end-tidal PCO2 (between +5 and +15 torr above the eupnoeic level) and/or PO2 (between 80 and 45 torr) were studied at rest and during mild cycle ergometer exercise. There was often alternation in inspiratory and expiratory tidal volumes and mean flows, and in expiratory duration, but not in inspiratory duration. The latency of responses, estimated by cross-correlation, corresponded closely to the lung-ear transport delay (measured by oximetry). There were two general patterns of response: in-phase, with inspiratory responses leading expiratory, and, more often, out-of-phase, with expiratory responses leading inspiratory. These patterns were associated with arrival of the onset of the alternating signal at the ear in inspiration and expiration, respectively. It is concluded that the timing of alternating humoral signals at the carotid bodies in relation to the phase of respiration determines the pattern of inspiratory-expiratory response, and that expiratory events can be independent of the previous inspiration.
研究了三名健康成年人在静息状态和轻度蹬车运动期间，对呼气末二氧化碳分压（在平静呼吸水平之上 +5 至 +15 托之间）和/或氧分压（在 80 至 45 托之间）施加的交替呼吸振荡的逐次呼吸呼吸反应。吸气和呼气潮气量、平均流量以及呼气持续时间常常会交替变化，但吸气持续时间不变。通过互相关估计的反应潜伏期与肺 - 耳传输延迟（通过血氧测定法测量）密切对应。反应有两种一般模式：同相，吸气反应先于呼气；更常见的是异相，呼气反应先于吸气。这些模式分别与交替信号在吸气和呼气时到达耳部的起始时间相关。得出的结论是，颈动脉体处交替体液信号相对于呼吸相位的时间决定了吸气 - 呼气反应模式，并且呼气事件可以独立于先前的吸气。
