Ward S A, Cunningham D J
Respir Physiol. 1977 May;29(3):379-90. doi: 10.1016/0034-5687(77)90011-1.
Four healthy young men and women, selected for the responsiveness and steadiness of their breathing, were studied in rest and mild exercise (58 runs) while receiving alternate inspirates of low and high PCO2 (0 and 8.6 kPa). PACO2 oscillated between ca. 6 and 7.5 kPa (45-55 torr); PACO2 was held steady at more than one level between 6 and 9.6 kPa (45-72 torr). Using cross-correlation analysis, the phase relations were determined between the alternating PACO2 and the following reflex outputs: mean inspiratory and expiratory flows (VI and VE) and the reciprocal of the duration of expiration (1/TE), the two expiratory variables being lumped together for purposes of expression, but not of calculation. T1, being relatively unaffected alternating PACO2, was not re-studied (see companion paper). The common patterns of significant reflex alternation were: VI alone, usually in phase (with PACO2), 24%; VE alone, usually in phase, 17%; both inspiratory and expiratory variables, in phase with CO2 and each other, 15%; both inspiratory and expiratory variables, the expiratory being out of phase with both CO2 and with the inspiratory, 23%. Some runs showed a mixture of phase relations. In 71%, end-expiratory lung volume (VL,E' formerly called FRC) alternated significantly. It is concluded that expiratory events can be influenced by peripheral chemoreceptors independently of inspiration.
挑选了四名呼吸反应灵敏且稳定的健康青年男女，在静息状态和轻度运动状态下（共58次测试）对他们进行研究，期间让他们交替吸入低二氧化碳分压（PCO2）和高二氧化碳分压（0和8.6千帕）的气体。动脉血二氧化碳分压（PACO2）在约6至7.5千帕（45 - 55托）之间波动；PACO2在6至9.6千帕（45 - 72托）之间的多个水平上保持稳定。使用互相关分析，确定了交替变化的PACO2与以下反射输出之间的相位关系：平均吸气流量和呼气流量（VI和VE）以及呼气持续时间的倒数（1/TE），为便于表述，将两个呼气变量合并在一起，但计算时并非如此。由于吸气时间（T1）相对不受交替变化的PACO2影响，因此未重新研究（见配套论文）。显著反射交替的常见模式有：仅VI，通常同相（与PACO2），占24%；仅VE，通常同相，占17%；吸气和呼气变量均同相，与二氧化碳及彼此同相，占15%；吸气和呼气变量均存在，呼气与二氧化碳及吸气均不同相，占23%。一些测试显示出相位关系的混合情况。在71%的测试中，呼气末肺容积（VL,E，以前称为功能残气量（FRC））有显著交替变化。得出的结论是，呼气事件可受外周化学感受器独立于吸气的影响。
