Britton B J, Hawkey C, Wood W G, Peele M
Br J Surg. 1974 Oct;61(10):814-20. doi: 10.1002/bjs.1800611016.
The changes in blood coagulation, fibrinolysis and sympatho–adrenal activity have been studied in 30 patients before, during and after elective surgery. The significance of adrenaline in the causation of the changes in coagulation and fibrinolysis has been investigated in three experimental models, using in man the adrenergic stimulus produced by exercise and in sheep the adrenergic stimulus produced by haemorrhage. During exercise in man the coagulation change closely correlated with the adrenaline response but fibrinolysis did not. Furthermore, the coagulation response was modified by beta adrenergic blockade with propranolol, oxprenolol, pindolol and butoxamine but not practolol, suggesting that this response was mediated by the beta−2 adrenergic receptor. Fibrinolysis was not inhibited by these drugs. Substantiation and development of these findings could lead to a new approach to the problem of venous thrombosis by inhibiting the coagulation changes that occur with surgery, without altering the fibrinolytic response.
我们对30例择期手术患者在手术前、手术期间和手术后的血液凝固、纤维蛋白溶解和交感-肾上腺活动变化进行了研究。我们使用人体运动产生的肾上腺素能刺激以及绵羊出血产生的肾上腺素能刺激，在三种实验模型中研究了肾上腺素在凝血和纤维蛋白溶解变化成因中的作用。在人体运动期间，凝血变化与肾上腺素反应密切相关，但纤维蛋白溶解则不然。此外，使用普萘洛尔、氧烯洛尔、吲哚洛尔和布托沙明进行β-肾上腺素能阻滞可改变凝血反应，但醋氨心安则无此作用，这表明该反应是由β-2肾上腺素能受体介导的。这些药物并未抑制纤维蛋白溶解。这些发现的证实和发展可能会带来一种新的方法来解决静脉血栓形成问题，即通过抑制手术时发生的凝血变化，而不改变纤维蛋白溶解反应。
