Norkrans G, Frösner G, Iwarson S
Scand J Gastroenterol. 1979;14(3):289-93. doi: 10.3109/00365527909179885.
A radioimmunoassay was used to determine the presence of the hepatitis B e antigen (HBeAg) and anti-HBe in the serum of 12 hepatitis B patients, who were follofed from an early phase of the illness into convalescence. The duration of detectable HBeAg in serum from these patients, in all ow whom the disease ran a normal course, was compared with the persistence of HBeAg in serum of nine patients with a protracted course and persistence of HBsAg in serum for more than 1 year. None of the hepatitis B patients with a normal course of the disease had HBeAg demonstrable for more than 9 weeks after the onset of illness (mean 5.4 weeks), whereas all patients developing chronic hepatitis had HBeAg in serum for more than 1 year after the onset of illness. These findings indicate that the detection of HBeAg in serum by radioimmunoassay for 10 weeks or more after the onset of illness implies a great risk of progression of the hepatitis B infection to chronic liver disease.
采用放射免疫分析法检测了12例乙型肝炎患者血清中乙型肝炎e抗原（HBeAg）和抗-HBe，这些患者从疾病早期开始随访直至康复。将这些疾病呈正常病程的患者血清中可检测到HBeAg的持续时间，与9例病程迁延且血清中HBsAg持续存在超过1年的患者血清中HBeAg的持续时间进行了比较。疾病呈正常病程的乙型肝炎患者在发病后9周以上均未检测到HBeAg（平均5.4周），而所有发展为慢性肝炎的患者在发病后1年以上血清中仍有HBeAg。这些发现表明，发病后10周或更长时间通过放射免疫分析法检测血清中的HBeAg意味着乙型肝炎感染进展为慢性肝病的风险很大。
