乙肝疫苗：对先前已感染乙肝表面抗原血症儿童的进一步研究
Hepatitis B vaccine: further studies in children with previously acquired hepatitis B surface antigenemia.
作者信息
Barin F, Yvonnet B, Goudeau A, Coursaget P, Chiron J P, Denis F, Mar I D
出版信息
Infect Immun. 1983 Jul;41(1):83-7. doi: 10.1128/iai.41.1.83-87.1983.
Three doses of inactivated hepatitis B vaccine were given at 1-month intervals to 31 hepatitis B surface antigen (HBsAg)-positive Senegalese children aged between 3 and 24 months. A control group of 18 HBsAg-positive Senegalese children received diphtheria-tetanus-polio vaccine. Immunization of HBsAg-positive infants with hepatitis B vaccine was safe but inefficient. After a 12-month follow-up, the prevalence of HBsAg chronic carriers was not significantly reduced in the hepatitis B vaccine group as compared with the control group: 48.4 and 66.7%, respectively. The presence of hepatitis B antigen was found to be a major risk factor for HBsAg-positive children to develop a chronic carrier state. The risk of developing an HBsAg chronic carrier state was also related to advancing age at time of enrollment in the study.
对31名年龄在3至24个月之间的乙型肝炎表面抗原（HBsAg）阳性的塞内加尔儿童，每隔1个月接种3剂乙型肝炎灭活疫苗。18名HBsAg阳性的塞内加尔儿童组成的对照组接种白喉-破伤风-脊髓灰质炎疫苗。对HBsAg阳性婴儿接种乙型肝炎疫苗是安全的，但效果不佳。经过12个月的随访，与对照组相比，乙型肝炎疫苗组中HBsAg慢性携带者的患病率没有显著降低，分别为48.4%和66.7%。发现乙型肝炎抗原的存在是HBsAg阳性儿童发展为慢性携带者状态的主要危险因素。发展为HBsAg慢性携带者状态的风险也与研究入组时年龄的增长有关。
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