Schwartz T W, Stenquist B, Olbe L
Scand J Gastroenterol. 1979;14(3):313-20. doi: 10.3109/00365527909179889.
The effect of sham feeding on pancreatic-polypeptide (PP) secretion was studied in 26 duodenal ulcer (DU) patients and in 8 healthy subjects. Modified sham feeding (MSF) by the 'chew and spit' technique induced a rapid increase in plasma concentrations of PP both in DU patients, 56 (2-138) pmol/l, and in the healthy subjects, 24 (2-45) pmol/l, median peak-increment and range. Four out of 26 DU patients and 2 out of 8 healthy subjects did not show any PP response to MSF. The PP response to MSF was abolished by pretreatment with atropine, or benzilonium, a quarternary anti-muscarinic agent with minimal cerebral actions. The PP response to MSF was not dependent on the gastric acid response, since a PP response to sham feeding was found in 13 out of 17 patients with selectively denervated parietal cell area, and thus, without acid response. During adequate sham feeding, in which the food is also swallowed but does not reach the stomach, the PP increment, 100 (81-129) pmol/l, was larger than during MSF in the same patients, 51 (8-78) pmol/l, median and total range, P less than 0.05, N = 7. No correlation was found between the PP and acid responses to sham feeding. It is concluded that cephalic stimulation provoked by tasting, chewing and swallowing is a major stimulus in the initial, rapid PP response during a meal; and that the PP cells are probably stimulated directly by a cholinergic mechanism.
在26例十二指肠溃疡（DU）患者和8名健康受试者中研究了假饲对胰多肽（PP）分泌的影响。采用“咀嚼并吐出”技术进行的改良假饲（MSF）使DU患者血浆PP浓度迅速升高，中位数峰值增量及范围为56（2 - 138）pmol/l，健康受试者为24（2 - 45）pmol/l。26例DU患者中有4例、8名健康受试者中有2例对MSF未表现出任何PP反应。用阿托品或苯磺铵（一种脑作用极小的季铵类抗毒蕈碱剂）预处理可消除对MSF的PP反应。对MSF的PP反应不依赖于胃酸反应，因为在17例壁细胞区选择性去神经支配的患者中有13例对假饲有PP反应，因此无酸反应。在适当的假饲过程中，食物也被咽下但未到达胃，此时PP增量为100（81 - 129）pmol/l，大于同一患者在MSF时的增量51（8 - 78）pmol/l，中位数及全距，P<0.05，N = 7。假饲时PP反应与酸反应之间未发现相关性。结论是，进餐期间由品尝、咀嚼和吞咽引起的头期刺激是PP初始快速反应的主要刺激因素；并且PP细胞可能直接通过胆碱能机制受到刺激。
