Bowen J C, Fleming W H
Ann Surg. 1974 Nov;180(5):760-4. doi: 10.1097/00000658-197411000-00009.
The effect of change in red cell 2,3-diphosphoglycerate concentration after transfusion of ACD stored blood on arteriovenous oxygen content difference, arteriovenous oxygen tension difference and oxygen consumption was assessed in 15 injured patients in Vietnam. A significant increase in the arteriovenous oxygen tension difference and oxygen consumption was observed at the time of low 2,3-DPG. Change in 2,3-DPG did not correlate, however, with change in either arteriovenous oxygen content difference or venous PO(2). This study suggests that alterations in oxyhemoglobin affinity are effectively compensated, possibly by opening capillaries to increase blood flow to tissues, by reducing the capillary-tissue oxygen gradient to maintain the rate of tissue oxygen extraction, or by increasing cardiac output.
在越南，对15名受伤患者输注ACD保存血后红细胞2,3 - 二磷酸甘油酸（2,3-DPG）浓度变化对动静脉氧含量差、动静脉氧分压差值和氧消耗的影响进行了评估。在2,3-DPG水平较低时，观察到动静脉氧分压差值和氧消耗显著增加。然而，2,3-DPG的变化与动静脉氧含量差或静脉血氧分压（PO₂）的变化均无相关性。该研究表明，氧合血红蛋白亲和力的改变可能通过开放毛细血管以增加组织血流量、降低毛细血管 - 组织氧梯度以维持组织氧摄取率或增加心输出量而得到有效补偿。
