Stein B M
Surg Neurol. 1979 May;11(5):331-7.
Utilizing the Krause exposure, we have operated on 21 cases of tumors of the pineal region encountering a wide variety of histology with an overall 30% incidence of benign lesions. There has been no significant morbidity in the post-operative management of these patients and one surgical death in a patient with a highly malignant glioma who developed a delayed hemorrhage into the tumor following the operation. In those tumors of recognized malignancy, post-operative radiotherapy has been utilized. In tumors of the germinoma, variety radiation of the entire neural axis is advocated. Since many of the patients have undergone radiotherapy prior to our exposure of the pineal tumor, we have had an opportunity to witness the effects of radiation on this region. In those cases of benign tumors we have found dense adhesions between the tumor and the brain, making definitive surgical treatment of the tumor more difficult.
采用克劳斯入路,我们对21例松果体区肿瘤进行了手术,这些肿瘤组织学类型多样,良性病变的总体发生率为30%。这些患者术后管理中没有明显的并发症,1例高度恶性胶质瘤患者术后出现肿瘤延迟出血导致手术死亡。对于那些确诊为恶性的肿瘤,采用了术后放疗。对于生殖细胞瘤,主张对整个神经轴进行多种放疗。由于许多患者在我们暴露松果体肿瘤之前就已经接受了放疗,我们有机会观察到放疗对该区域的影响。在那些良性肿瘤病例中,我们发现肿瘤与脑之间有致密粘连,这使得肿瘤的确定性手术治疗更加困难。