Galbraith P R
Can Med Assoc J. 1974 Nov 2;111(9):919-23.
Leukocyte kinetic studies were performed by labelling neutrophilic leukocytes in vivo with radioactive diisopropylfluorophosphate and measuring the time taken for the label to traverse the myelocyte compartment, marrow granulocyte reservoir and blood (myelocyte-to-tissue transit time). Leukocyte specific activity (LSA) reached background levels within 17 to 22 days in normal subjects and more rapidly than normal in patients with neutropenia due to hypersplenism or marrow aplasia. When neutropenia was partially or completely corrected by splenectomy the label disappeared more slowly. In patients with stable neutrophilia the label disappeared slowly and a terminal plateau in the LSA curve was encountered. Analysis of LSA curves suggests that disappearance of labelled neutrophil cohorts is influenced by circulating neutrophil levels, not only by an effect on release of cells from the marrow granulocyte reservoir but also, directly or indirectly, by an effect on myelocyte proliferation.
通过用放射性二异丙基氟磷酸在体内标记嗜中性白细胞，并测量标记物穿过中幼粒细胞区室、骨髓粒细胞储存库和血液所需的时间（中幼粒细胞到组织的转运时间），进行白细胞动力学研究。在正常受试者中，白细胞比活性（LSA）在17至22天内达到本底水平，而在因脾功能亢进或骨髓再生障碍导致中性粒细胞减少的患者中，其达到本底水平的速度比正常情况更快。当通过脾切除术使中性粒细胞减少部分或完全得到纠正时，标记物消失得更慢。在患有持续性中性粒细胞增多症的患者中，标记物消失缓慢，并且在LSA曲线中出现终末平台期。对LSA曲线的分析表明，标记的中性粒细胞群体的消失受循环中性粒细胞水平的影响，这不仅是因为对骨髓粒细胞储存库中细胞释放的影响，还直接或间接地因为对中幼粒细胞增殖的影响。
