Bilich G L, Zagaĭnov E A, Otmakhov V N, Nazarova L V, Sungurova E V
Vestn Khir Im I I Grek. 1979 Feb;122(2):48-53.
The effect of orotic acid on the development of compensatory pulmonary hypertrophy has been studied in the clinic and in the experiments (71 patients, and 349 rats) carried out with the use of morphologic, biochemical cytochemical, immunologic and clinical methods, and also through autoradiography. The results of the study prove the effect of the drug upon the pulmonary regeneration. Experimental findings have shown that behind the stimulating effect of the drug there is the activation of the synthesis of nucleinic acids, the rise of the mitotic activity of the interalveolar membranes cells of the lung remnants. An essential increase of the lymphocytic dehydrogenase activity of the peripheral blood occurred in response to the effect of the drug.
已通过形态学、生化细胞化学、免疫学和临床方法以及放射自显影技术，在临床和实验中（71例患者和349只大鼠）研究了乳清酸对代偿性肺肥大发展的影响。研究结果证明了该药物对肺再生的作用。实验结果表明，该药物的刺激作用背后是核酸合成的激活，肺残余部分肺泡间膜细胞有丝分裂活性的增加。外周血淋巴细胞脱氢酶活性因药物作用而显著增加。
