Bilich G L
Ontogenez. 1982 Jul-Aug;13(4):387-94.
The materials on lung regeneration are generalized, the prerequisites for the stimulation of compensatory hypertrophy of the lung tissue are considered, the results of application of regeneration stimulators in the experimental and clinical conditions are first systematized and analyzed. Experiments were carried on over 3,500 animals with the use of complex morphometrical, biochemical, autoradiographical, morphological, cytochemical methods; the functional state of lung tissue was evaluated under the conditions of application of regeneration stimulators. The application of purines and pyrimidines contributes to a more complete and rapid development of compensatory hypertrophy of the lung, restoration of the total alveolar surface, leads to the formation of alveoli de novo, prevents the appearance of the phenomena of morphological and functional decompensation at remote times after the operation, excludes the development of pneumofibrosis. The mechanisms of the stimulating effect of the drugs in question on the development of compensatory hypertrophy of the lung are revealed, a new classification is proposed.
对肺再生的材料进行了综述，探讨了刺激肺组织代偿性肥大的前提条件，首次对再生刺激剂在实验和临床条件下的应用结果进行了系统整理和分析。使用复杂的形态计量学、生物化学、放射自显影、形态学、细胞化学方法对3500多只动物进行了实验；在应用再生刺激剂的条件下评估肺组织的功能状态。嘌呤和嘧啶的应用有助于肺代偿性肥大更完整、快速地发展，恢复肺泡总表面积，导致肺泡新生，防止术后远期出现形态和功能失代偿现象，排除肺纤维化的发生。揭示了上述药物对肺代偿性肥大发展的刺激作用机制，并提出了新的分类方法。
