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雌性大鼠发情周期、怀孕、分娩及产褥期的血浆激肽和激肽原水平。

Plasma kinin and kininogen levels in the female rat during the oestrous cycle, pregnancy, parturition and the puerperium.

作者信息

McCormick J T, Senior J

出版信息

Br J Pharmacol. 1974 Feb;50(2):237-41. doi: 10.1111/j.1476-5381.1974.tb08567.x.

DOI:10.1111/j.1476-5381.1974.tb08567.x
PMID:4425762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776637/
Abstract

1 Plasma kininogen concentration of the female rat did not change during the oestrous cycle but increased two-fold during gestation. Plasma kininogen did not change during parturition, rose in the first puerperal day and then rapidly declined to non-pregnant levels.2 Free kinin levels in the blood of non-pregnant female rats were low and inconstant. Free kinin was undetectable in the blood of pregnant rats, but was found in four out of ten parturient rats.3 After administration of the kininase inhibitor dimercaprol (30 mg/kg i.p.), free kinin was present in the blood of six parturient rats. Dimercaprol caused appearance of free kinin in the blood of only one out of six non-pregnant rats.4 It appears that the plasma kinin system is activated to a small degree during parturition.

摘要

  1. 雌性大鼠血浆激肽原浓度在发情周期中无变化，但在妊娠期增加两倍。血浆激肽原在分娩期间无变化，在产后第一天升高，然后迅速降至非妊娠水平。

  2. 未妊娠雌性大鼠血液中的游离激肽水平较低且不稳定。妊娠大鼠血液中未检测到游离激肽，但在十分之四的分娩大鼠中发现了游离激肽。

  3. 给予激肽酶抑制剂二巯丙醇（30毫克/千克腹腔注射）后，六只分娩大鼠的血液中出现了游离激肽。二巯丙醇仅使六只未妊娠大鼠中的一只血液中出现了游离激肽。

  4. 看来血浆激肽系统在分娩期间有轻度激活。

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Plasma kinin and kininogen levels in the female rat during the oestrous cycle, pregnancy, parturition and the puerperium.雌性大鼠发情周期、怀孕、分娩及产褥期的血浆激肽和激肽原水平。
Br J Pharmacol. 1974 Feb;50(2):237-41. doi: 10.1111/j.1476-5381.1974.tb08567.x.
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引用本文的文献

1
Changes in plasma kininogen levels induced by cellulose sulphate during pregnancy in the rat.大鼠孕期硫酸纤维素诱导的血浆激肽原水平变化。
Br J Pharmacol. 1974 Dec;52(4):533-7. doi: 10.1111/j.1476-5381.1974.tb09721.x.
2
Plasma kininogen during the oestrous cycle, early pregnancy and pseudopregnancy in the rat.大鼠发情周期、早期妊娠和假孕期间的血浆激肽原。
J Physiol. 1976 Mar;256(1):167-74. doi: 10.1113/jphysiol.1976.sp011318.
3
The action of bradykinin and oxytocin on the isolated whole uterus and myometrium of the rat in oestrus.缓激肽和催产素对处于发情期的大鼠离体全子宫和子宫肌层的作用。
Br J Pharmacol. 1978 Sep;64(1):21-8. doi: 10.1111/j.1476-5381.1978.tb08636.x.

本文引用的文献

1
A micromethod for determination of bradykininogen under several conditions.一种在多种条件下测定缓激肽原的微量方法。
Ann N Y Acad Sci. 1963 Feb 4;104:77-89. doi: 10.1111/j.1749-6632.1963.tb17654.x.
2
Oxytocic activity of blood in parturient and lactating women.产妇和哺乳期妇女血液的催产活性。
J Clin Endocrinol Metab. 1961 Aug;21:985-95. doi: 10.1210/jcem-21-8-985.
3
Estrogen secretion by the rat ovary in vivo during the estrous cycle and pregnancy.大鼠卵巢在发情周期和妊娠期的体内雌激素分泌。
Endocrinology. 1969 Jul;85(1):103-12. doi: 10.1210/endo-85-1-103.
4
[The kininogen level or rats and rabbits during gestation].妊娠期大鼠和家兔的激肽原水平
Experientia. 1968 Nov 15;24(11):1128-9. doi: 10.1007/BF02147802.
5
[The kininogen content of plasma and amniotic fluid].[血浆和羊水的激肽原含量]
Acta Biol Med Ger. 1967;19(1):61-71.
6
Effect of sex hormones on the concentrations of plasma kininogen in the female rat.性激素对雌性大鼠血浆激肽原浓度的影响。
Br J Pharmacol. 1971 Oct;43(2):421P-422P.
7
The effect of the oestrous cycle, pregnancy and reproductive hormones on the kininase activity of rat blood.发情周期、妊娠及生殖激素对大鼠血液激肽酶活性的影响。
J Reprod Fertil. 1972 Sep;30(3):381-7. doi: 10.1530/jrf.0.0300381.
8
Secretion rates of oestrogens into the ovarian venous blood of pregnant rats.雌激素向妊娠大鼠卵巢静脉血中的分泌率。
J Reprod Fertil. 1972 Feb;28(2):191-6. doi: 10.1530/jrf.0.0280191.
9
Plasma kinin and kininogen levels in women during pregnancy and in labour.孕期及分娩期女性血浆激肽和激肽原水平
J Reprod Fertil. 1972 Aug;30(2):247-54. doi: 10.1530/jrf.0.0300247.

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