大鼠孕期硫酸纤维素诱导的血浆激肽原水平变化。
Changes in plasma kininogen levels induced by cellulose sulphate during pregnancy in the rat.
作者信息
McCormick J T, Senior J, Whalley E T
出版信息
Br J Pharmacol. 1974 Dec;52(4):533-7. doi: 10.1111/j.1476-5381.1974.tb09721.x.
1 Cellulose sulphate (1 mg/kg) produced a 30-40% depletion of plasma kininogen in rats.2 The time course of repletion of kininogen in the plasma was compared in rats in the oestrous and dioestrous stages of the cycle and in 22 day pregnant animals. A partial repletion occurred, 3 h after the cellulose sulphate injection, which was followed by a secondary fall in plasma kininogen. Plasma kininogen values were back to control levels 10 h after the treatment in all groups.3 Treatment of rats from days 19-22 of pregnancy with cellulose sulphate resulted in 40% depletion of plasma kininogen and in prolongation of pre-parturition behaviour.4 It is suggested that the increase which normally occurs in plasma kininogen levels towards the end of pregnancy in the rat may play a role in the process of parturition.
硫酸纤维素（1毫克/千克）使大鼠血浆激肽原减少30 - 40%。
比较了处于发情周期的动情期和间情期的大鼠以及怀孕22天的动物血浆中激肽原补充的时间进程。注射硫酸纤维素3小时后出现部分补充，随后血浆激肽原再次下降。所有组在治疗10小时后血浆激肽原值恢复到对照水平。
用硫酸纤维素处理怀孕19 - 22天的大鼠，导致血浆激肽原减少40%，并使产前行为延长。
有人提出，大鼠妊娠末期血浆激肽原水平通常的升高可能在分娩过程中起作用。
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