Cameron J S, Chantler C, Ogg C S, White R H
Br Med J. 1974 Oct 5;4(5935):7-11. doi: 10.1136/bmj.4.5935.7.
Fifty-eight children with minimal-change nephrotic lesions who relapsed repeatedly and showed toxic side effects from corticosteroids were treated with cyclophosphamide for an average of 12 weeks. The initial dose was 5 mg/kg/day. Four to seven years (mean 5.8 years) later 20 remained in remission, 34 were still relapsing, and 4 had died (two during relapses, one of measles after cyclophosphamide, and one of a brain-stem astrocytoma). The half time for the relapse-free period after treatment was 2.8 years. There was no relationship between the length of treatment with cyclophosphamide and the stability of remission within the limits studied.
58名患有微小病变性肾病且反复复发并出现皮质类固醇毒性副作用的儿童接受了环磷酰胺治疗，平均治疗时间为12周。初始剂量为5毫克/千克/天。4至7年（平均5.8年）后，20名儿童仍处于缓解期，34名仍在复发，4名已死亡（2名在复发期间死亡，1名在环磷酰胺治疗后死于麻疹，1名死于脑干星形细胞瘤）。治疗后无复发期的半衰期为2.8年。在所研究的范围内，环磷酰胺治疗时间的长短与缓解的稳定性之间没有关系。
