Brusova E G, Krivchenkova R S
Vopr Med Khim. 1979 Mar-Apr;25(2):198-204.
Statistically significant inhibition of oxidative deamination of several biogenic amines was found in mitochondrial fraction of heart muscle from rabbits and rats with experimental atherosclerosis and hypercholesterolemia, caused by various methods. Sensitivity of oxidative deamination of tryptamine to inhibitory effect of clorgyline (selective inhibitor of mitochondrial monoamine oxidases) was unaltered in rats with experimental hypercholesterolemia. The rate of oxidative deamination of beta-phenyl ethylamine, tryptamine, benzylamine as well as histamine and putrescine was inhibited after treatment of the mitochondrial fragments from healthy rabbit and rat heart muscles with preparations of oxidized linoleic and linolenic acids, concentration of which was increased in tissues under conditions of atherosclerosis.
在采用各种方法诱发实验性动脉粥样硬化和高胆固醇血症的家兔和大鼠的心肌线粒体部分中，发现几种生物胺的氧化脱氨作用受到了具有统计学意义的抑制。在实验性高胆固醇血症大鼠中，色胺氧化脱氨对氯吉兰（线粒体单胺氧化酶的选择性抑制剂）抑制作用的敏感性未发生改变。在用氧化亚油酸和亚麻酸制剂处理健康家兔和大鼠心肌线粒体片段后，β-苯乙胺、色胺、苄胺以及组胺和腐胺的氧化脱氨速率受到抑制，在动脉粥样硬化条件下，这些组织中氧化亚油酸和亚麻酸的浓度会升高。
