Awadallah R, Tahani H M, El-Dessoukey E A
Z Ernahrungswiss. 1979 Mar;18(1):1-7. doi: 10.1007/BF02026530.
The intravenous injection of zinc or manganese chloride immediately before and 15 minutes after alloxan or dithizone prevented the usual hyperglycemia observed 24 hours after induction of diabetes. Injection of zinc chloride in alloxan diabetes led to normalization of sodium while zinc, copper, iron and magnesium remained high and calcium and potassium remained low as in alloxan. In case of dithizone diabetes, the administration of zinc salt led to an increase in serum zinc, magnesium and potassium and to a decrease in serum calcium while the sodium level returned to normal. Manganese plus alloxan led to a normalization of serum zinc, copper, potassium and sodium. In the case of dithizone plus manganese only magnesium was raised while the other elements were unchanged when compared to animals injected with dithizone only. Chromium and cobalt lowered the blood glucose to a certain extent however it did not affect most of the elements. The same changes occurred in all elements as with alloxan or dithizone alone. Pretreatment with ATP led to a normalization of serum zinc, copper, magnesium, sodium and potassium, while in case of iron it remained high and calcium remained low as that found in alloxan diabetic rats.
在注射四氧嘧啶或双硫腙之前及之后15分钟立即静脉注射锌或氯化锰，可预防糖尿病诱导后24小时出现的常见高血糖症。在四氧嘧啶糖尿病中注射氯化锌可使钠恢复正常，而锌、铜、铁和镁仍保持较高水平，钙和钾则如在四氧嘧啶糖尿病中一样保持较低水平。在双硫腙糖尿病中，给予锌盐会导致血清锌、镁和钾增加，血清钙减少，而钠水平恢复正常。锰加四氧嘧啶可使血清锌、铜、钾和钠恢复正常。在双硫腙加锰的情况下，与仅注射双硫腙的动物相比，仅镁含量升高，而其他元素未发生变化。铬和钴在一定程度上降低了血糖，但未影响大多数元素。所有元素出现的变化与单独使用四氧嘧啶或双硫腙时相同。用三磷酸腺苷预处理可使血清锌、铜、镁、钠和钾恢复正常，而铁仍保持较高水平，钙仍保持较低水平，与四氧嘧啶糖尿病大鼠的情况相同。
