垂体激素类似物的抑制特性及其对羧肽酶抗性的研究：（9-L-脯氨酸）催产素、（9-L-谷氨酸）催产素和（8-L-赖氨酸，9-甘氨酸甲酰胺）催产素。 - Suppr | 超能文献

Study of pituitary hormone analogs for their inhibitory properties and resistance to carboxamidopeptidases: (9-L-proline)oxytocin, (9-L-glutamic acid)oxytocin, and (8-L-lysine,9-glycine methylamide)oxytocin.

作者信息

Grzonka Z, Glass J D, Schwartz I L, Walter R

出版信息

J Med Chem. 1974 Dec;17(12):1294-8. doi: 10.1021/jm00258a013.

DOI:10.1021/jm00258a013

Abstract

摘要

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1

Study of pituitary hormone analogs for their inhibitory properties and resistance to carboxamidopeptidases: (9-L-proline)oxytocin, (9-L-glutamic acid)oxytocin, and (8-L-lysine,9-glycine methylamide)oxytocin.垂体激素类似物的抑制特性及其对羧肽酶抗性的研究：（9-L-脯氨酸）催产素、（9-L-谷氨酸）催产素和（8-L-赖氨酸，9-甘氨酸甲酰胺）催产素。

J Med Chem. 1974 Dec;17(12):1294-8. doi: 10.1021/jm00258a013.

2

(1-beta-mercapto-beta,beta-diethylpropionic acid,4-leucine)-8-lysine-vasopressin and (1-beta-mercapto-beta,beta-diethylpropionic acid,4-leucine)oxytocin, compounds possessing antihormonal properties.（1-β-巯基-β，β-二乙基丙酸，4-亮氨酸）-8-赖氨酸-加压素和（1-β-巯基-β，β-二乙基丙酸，4-亮氨酸）催产素，具有抗激素特性的化合物。

J Med Chem. 1974 Sep;17(9):969-72. doi: 10.1021/jm00255a012.

3

Synthetic metabolites of neurohypophyseal hormones. (Des-9-glycinamide)oxytocin and (des-9-glycinamide, des-8-leucine)oxytocin.

J Med Chem. 1976 Feb;19(2):328-30. doi: 10.1021/jm00224a025.

4

Synthesis and some of the pharmacological properties of (4-leucine)-8-lysine-vasopressin and (1-deamino,4-leucine)-8-lysine-vasopressin.（4-亮氨酸）-8-赖氨酸加压素和（1-去氨基，4-亮氨酸）-8-赖氨酸加压素的合成及其某些药理特性

J Med Chem. 1973 Jul;16(7):843-7. doi: 10.1021/jm00265a022.

5

Pharmacological effects of introducing a double bond into a binding site of oxytocin. Analogues with L-3,4-dehydroproline in position 7.将双键引入催产素结合位点的药理作用。7位含L-3,4-脱氢脯氨酸的类似物。

J Med Chem. 1977 Apr;20(4):495-500. doi: 10.1021/jm00214a007.

6

Combined high oxytocic with negligible antidiuretic and pressor activities in multisubstituted oxytocins.在多取代催产素中，结合了高催产活性以及可忽略不计的抗利尿和升压活性。

J Med Chem. 1977 Apr;20(4):492-5. doi: 10.1021/jm00214a006.

7

Synthesis and some pharmacological properties of (1-deamino,9-thioglycine)oxytocin.（1-脱氨基，9-硫代甘氨酸）催产素的合成及某些药理性质

J Am Chem Soc. 1973 Aug 22;95(17):5677-9. doi: 10.1021/ja00798a037.

8

Oxytocin analogues with combined high smooth muscle and negligible antidiuretic activities. Investigation of position 7 in neurohypophyseal hormones.具有高平滑肌活性和可忽略不计的抗利尿活性的催产素类似物。神经垂体激素中7位的研究。

J Med Chem. 1976 Jun;19(6):822-5. doi: 10.1021/jm00228a017.

9

Glutamine isomers of oxytocin and deamino-oxytocin: synthesis and pharmacological properties of [4-N4-methyl-L-asparagine]-oxytocin and [1-beta-mercaptopropionic acid, 4-N4-methyl-L-asparagine]-oxytocin.催产素和去氨基催产素的谷氨酰胺异构体：[4-N4-甲基-L-天冬酰胺]-催产素和[1-β-巯基丙酸，4-N4-甲基-L-天冬酰胺]-催产素的合成及药理特性

Mol Pharmacol. 1969 Jan;5(1):83-9.

10

[1-Beta-mercapto-beta,beta-pentamethylenepropionic acid]oxytocin, a potent inhibitor of oxytocin.[1-巯基-β,β-五亚甲基丙酸]催产素，一种强效催产素抑制剂。

J Med Chem. 1975 Mar;18(3):284-7. doi: 10.1021/jm00237a015.

引用本文的文献

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Revisiting oxytocin through the medium of isonitriles.重新审视异腈媒介下的催产素。

J Am Chem Soc. 2012 Aug 15;134(32):13244-7. doi: 10.1021/ja3063452. Epub 2012 Aug 2.