Andersen J R, Eikard B
Acta Anaesthesiol Scand. 1979 Apr;23(2):182-8. doi: 10.1111/j.1399-6576.1979.tb01439.x.
The effect of a single dose of suxamethonium on cardiac rate and rhythm during halothane anesthesia with babiturate induction was studied in a prospective, triple-blind trial with 28 patients. No atropine was given and patients were not intubated. A slight but significant preponderance of sinus-bradycardia without hemodynamic consequences was found in the group given suxamethonium. Suxamethonium did not provoke ventricular ectopies or conduction disturbances. It is concluded that in anesthesia with barbiturate induction, but without atropine or intubation, the use of a single dose of suxamethonium is a safe procedure with regard to cardiac rate and rhythm.
在一项有28名患者参与的前瞻性三盲试验中,研究了在巴比妥类药物诱导的氟烷麻醉期间,单次注射琥珀胆碱对心率和心律的影响。未给予阿托品,患者也未进行插管。在给予琥珀胆碱的组中发现了轻微但显著的窦性心动过缓优势,且无血流动力学后果。琥珀胆碱未引发室性早搏或传导障碍。得出的结论是,在巴比妥类药物诱导的麻醉中,但未使用阿托品或未进行插管时,单次使用琥珀胆碱在心率和心律方面是一种安全的操作。