Dymling J F, Lidgren L, Wallöe A
Acta Med Scand. 1979;205(5):401-4. doi: 10.1111/j.0954-6820.1979.tb06072.x.
Five biochemical variables, S-Ca, U-Ca, S-P, U-P and S-ALP, all involved in calcium metabolism, have been investigated in 86 epileptics on long-term medication. We found hypocalciuria in half of the epileptics and increased S-ALP in one third. In contrast to earlier reports there was no hypocalcemia, whereas hypercalcemia was found in 7 epileptics. We have previously reported a high frequency of fractures in these epileptics. An increased fracture rate was found in the 13 epileptics with both hypocalciuria and increased S-ALP, indicating osteomalacia.
对86名长期服药的癫痫患者的5种参与钙代谢的生化指标进行了研究，这5种指标分别为血清钙（S-Ca）、尿钙（U-Ca）、血清磷（S-P）、尿磷（U-P）和血清碱性磷酸酶（S-ALP）。我们发现，一半的癫痫患者存在尿钙过少，三分之一的患者血清碱性磷酸酶升高。与早期报告不同的是，未发现低钙血症，而7名癫痫患者出现了高钙血症。我们之前报道过这些癫痫患者骨折发生率较高。在13名同时存在尿钙过少和血清碱性磷酸酶升高的癫痫患者中发现骨折发生率增加，提示存在骨软化症。
