Kannel W B, Gordon T, Castelli W P
Am J Clin Nutr. 1979 Jun;32(6):1238-45. doi: 10.1093/ajcn/32.6.1238.
Some lipid and lipoprotein accompaniments of obesity and its association with glucose intolerance are examined in the Framingham cohort of 5209 men and women ages 30 to 59 examined biennially over 18 years. While beta and pre-beta lipoproteins were positively correlated with relative weight, high density lipoprotein cholesterol was inversely correlated. The association was strongest for high density lipoprotein cholesterol, varying little by age and sex. Triglyceride was a close second, but unlike high density lipoproteins, it and other lipids were more closely associated with obesity in men than women and in younger than older persons. Obese persons tended to have a greater likelihood of glycosuria and an increasing prevalence of diabetes. Relative weight in the Framingham cohort rose in both sexes to age 54, remained essentially unchanged until age 62 and then began to decline. Despite such changes body weights even 18 years apart had a correlation of 0.8. Men from each succeeding birth cohort were heavier, women were lighter, but even women from the most recent birth cohort were much more frequently above "desirable" weight than below it.
在弗雷明汉队列研究中，对5209名年龄在30至59岁之间的男性和女性进行了为期18年的每两年一次的检查，以研究肥胖的一些脂质和脂蛋白伴随情况及其与葡萄糖不耐受的关系。虽然β脂蛋白和前β脂蛋白与相对体重呈正相关，但高密度脂蛋白胆固醇呈负相关。这种关联在高密度脂蛋白胆固醇方面最为显著，年龄和性别差异不大。甘油三酯紧随其后，但与高密度脂蛋白不同的是，它和其他脂质在男性中与肥胖的关联比女性更强，在年轻人中比老年人更强。肥胖者出现糖尿的可能性更大，糖尿病患病率也在上升。弗雷明汉队列研究中的相对体重在男女中均在54岁时上升，直到62岁基本保持不变，然后开始下降。尽管有这些变化，但相隔18年的体重仍有0.8的相关性。每一个后续出生队列的男性体重更重，女性体重更轻，但即使是最近出生队列的女性，体重超过“理想”体重的频率也远高于低于“理想”体重的频率。
