Mori J, Hashimoto M, Mukumoto S, Honda F
Jpn J Pharmacol. 1979 Dec;29(6):913-21. doi: 10.1254/jjp.29.913.
The metabolism of L-5HTP by the rat exocrine pancreas, and effects of blockers on the metabolism were studied by fluorescent histochemical and chemical methods. Histochemically, 5-hydroxytryptamine (5-HT) blockers (methyserigide and cyprohepatdine) and dopamine (DA) blockers (haloperidol and sulpiride) produced no apparent changes in fluorescence pictures after injection of L-5HTP. alpha-blockers (phenoxybenzamine and phentolamine) and monoamine oxidase (MAO) inhibitor (iproniazide) produced an increased accumulation of 5-HT fluorescence in the apical regions of acinar cells where the zymogen granules are stored. Chemically, the 5-HT blockers decreased the 5-HT content after injection of L-5HPT. Sulpiride had no effect. Haloperidol decreased the 5-HT content. MAO inhibitor resulted in a vast accumulation of L-dopa: e.g. (1) L-5HTP was more slowly eliminated, and (2) 5-HT blockers produced a decreased content of 5-HT after injection of L-5HTP, in contrast to the finding that DA-blockers produced an incresed content of DA after injection of L-dopa. The mechanism responsible for the differences is discussed in relation to the possible pharmacological effects of L-5HTP and L-dopa on the secretion from the exocrine pancreas of rats.
采用荧光组织化学和化学方法研究了大鼠外分泌胰腺对L - 5羟色胺酸（L - 5HTP）的代谢以及阻滞剂对该代谢的影响。组织化学方面，注射L - 5HTP后，5 - 羟色胺（5 - HT）阻滞剂（麦角酰二乙胺和赛庚啶）以及多巴胺（DA）阻滞剂（氟哌啶醇和舒必利）未使荧光图像产生明显变化。α阻滞剂（酚苄明和酚妥拉明）和单胺氧化酶（MAO）抑制剂（异烟酰异丙肼）使5 - HT荧光在储存酶原颗粒的腺泡细胞顶端区域积累增加。化学方面，5 - HT阻滞剂在注射L - 5HPT后降低了5 - HT含量。舒必利无作用。氟哌啶醇降低了5 - HT含量。MAO抑制剂导致大量L - 多巴积累：例如，（1）L - 5HTP消除更慢，（2）与注射L - 多巴后DA阻滞剂使DA含量增加的结果相反，5 - HT阻滞剂在注射L - 5HTP后使5 - HT含量降低。结合L - 5HTP和L - 多巴对大鼠外分泌胰腺分泌可能的药理作用，讨论了造成这些差异的机制。
