Mori J, Satoh H, Satoh Y, Honda F
Jpn J Pharmacol. 1979 Dec;29(6):923-33. doi: 10.1254/jjp.29.923.
Effects of L-dopa, L-5HTP, a few amines, and related compounds on the pancreatic rate of flow, protein secretion, and bicarbonate secretion were studied in conscious rats. Single injections of L-dopa, DA and apomorphine did not modify the rate of flow, while an increase was seen with infusion of DA. L-dopa stimulated the protein secretion. L-5HTP and 5-HT decreased the rate of flow and protein secretion. Effects of L-dopa and L-5HTP on the protein secretion were prevented by DA- and 5-HT blockers, respectively. Neither L-dopa nor L-5HTP had any effect on the bicarbonate secretion. Secretin and cholinergic agents (acetylcholine and carbamylcholine) strongly stimulated the rate of flow of pancreatic juice. alpha-Agonists (phenylephrine and clonidine) decreased the rate of flow, and the effects were inhibited by an alpha-blocker. The alpha-agonists had no effect on protein secretion. Although, alpha-blockers (phenoxybenzamine and phentolamine) had no effects on the rate of flow, they did decrease the protein secretion. Isoproterenol was a potent secretagogue, and the effect was suppressed by a beta-blocker. Histamine had no effect on the rate of flow. The results were discussed in relation to our previous histochemical and chemical findings, and the species difference between rats and dogs in response to the amines.
在清醒大鼠中研究了左旋多巴、L-5-羟色氨酸、几种胺类及相关化合物对胰腺分泌率、蛋白质分泌和碳酸氢盐分泌的影响。单次注射左旋多巴、多巴胺和阿扑吗啡未改变分泌率，而输注多巴胺则使分泌率增加。左旋多巴刺激蛋白质分泌。L-5-羟色氨酸和5-羟色胺降低分泌率和蛋白质分泌。左旋多巴和L-5-羟色氨酸对蛋白质分泌的影响分别被多巴胺和5-羟色胺阻断剂所阻断。左旋多巴和L-5-羟色氨酸对碳酸氢盐分泌均无影响。促胰液素和胆碱能药物（乙酰胆碱和氨甲酰胆碱）强烈刺激胰液分泌率。α-激动剂（去氧肾上腺素和可乐定）降低分泌率，且这些作用被α-阻断剂抑制。α-激动剂对蛋白质分泌无影响。虽然α-阻断剂（酚苄明和酚妥拉明）对分泌率无影响，但它们确实降低了蛋白质分泌。异丙肾上腺素是一种强效促分泌剂，其作用被β-阻断剂抑制。组胺对分泌率无影响。结合我们之前的组织化学和化学研究结果以及大鼠和狗对胺类反应的种属差异对这些结果进行了讨论。
