Wittmann B K, Robinson H P, Aitchison T, Fleming J E
Am J Obstet Gynecol. 1979 May 1;134(1):30-5. doi: 10.1016/0002-9378(79)90791-9.
In an attempt to devise a screening method for the detection of unsuspected IUGR, a battery of ultrasonic measurements of the fetus were performed in a series of 255 patients at approximately 32, 34, and 36 weeks. The results obtained from the 16 growth-retarded and the 239 normally grown babies were evaluated. While no single measurement was found to discriminate the two groups, a simple combination of crown-rump length times area of trunk allowed us to identify an at-risk group comprising 11 per cent of the population. The false positive and false negative results were acceptable at levels of 10 and 6 per cent, approximately. It is considered that these results would justify a larger and prospectively randomized controlled trial to assess the benefits and drawbacks of applying these measurements in a screening schedule.
为了设计一种用于检测未被怀疑的胎儿生长受限(IUGR)的筛查方法,对255例患者在孕约32周、34周和36周时进行了一系列胎儿超声测量。对16例生长受限婴儿和239例正常生长婴儿的测量结果进行了评估。虽然没有发现单一测量方法能够区分这两组,但顶臀长乘以躯干面积的简单组合使我们能够识别出占人群11%的高危组。假阳性和假阴性结果分别约为10%和6%,这是可以接受的。据认为,这些结果足以证明有必要开展一项更大规模的前瞻性随机对照试验,以评估在筛查方案中应用这些测量方法的利弊。