Davis S D, Sarff L D, Hyndiuk R A
Am J Ophthalmol. 1979 May;87(5):710-6. doi: 10.1016/0002-9394(79)90309-x.
We determined the efficacy of tobramycin administered by topical, intramuscular, and subconjunctival routes in guinea pigs and rabbits with experimental Pseudomonas keratitis. The topical route of administration was consistently more effective than either subconjunctival or intramuscular routes. Subconjunctival injection of antibiotic did not enhance the effectiveness of topical therapy in either guinea pigs or rabbits. Intramuscular tobramycin was more effective than saline in guinea pigs with keratitis but not in rabbits with keratitis.
我们测定了妥布霉素经局部、肌肉注射和结膜下途径给药对患有实验性铜绿假单胞菌角膜炎的豚鼠和兔子的疗效。局部给药途径始终比结膜下或肌肉注射途径更有效。结膜下注射抗生素并未增强豚鼠或兔子局部治疗的效果。肌肉注射妥布霉素对患有角膜炎的豚鼠比生理盐水更有效，但对患有角膜炎的兔子则不然。
