Davis S D, Sarff L D, Hyndiuk R A
Arch Ophthalmol. 1978 Jan;96(1):126-8. doi: 10.1001/archopht.1978.03910050082021.
The effect of prednisolone on tobramycin and carbenicillin therapy for experimentally induced Pseudomonas keratitis was evaluated. Results were assessed quantitatively by determining the number of bacteria that survived in the cornea. Simultaneous administration of prednisolone did not adversely alter results of treatment with carbenicillin or tobramycin. In another trial, pretreatment with prednisolone for 48 hours before antibiotic therapy was begun did not change significantly the results of therapy with intramuscular tobramycin or carbenicillin. We conclude that corticosteroid therapy does not affect adversely results of antibiotic therapy with tobramycin or carbenicillin in this experimental model.
评估了泼尼松龙对妥布霉素和羧苄西林治疗实验性诱导的铜绿假单胞菌角膜炎的影响。通过测定角膜中存活的细菌数量对结果进行定量评估。同时给予泼尼松龙不会对羧苄西林或妥布霉素的治疗结果产生不利影响。在另一项试验中，在开始抗生素治疗前48小时用泼尼松龙预处理，并未显著改变肌肉注射妥布霉素或羧苄西林的治疗结果。我们得出结论，在该实验模型中，皮质类固醇治疗不会对抗生素妥布霉素或羧苄西林的治疗结果产生不利影响。
