Johnson A G, McDermott S J
Gut. 1974 Sep;15(9):710-3. doi: 10.1136/gut.15.9.710.
Lysolecithin is formed when pancreatic juice and bile mix in the duodenum. Lysolecithin concentrations have been measured in intermittent samples of night gastric juice from patients with gastric ulcers and duodenal ulcers and in normal controls. In gastric ulcer patients, the mean of the peak concentrations (444 mug/ml) and mean of concentrations in all samples (199 mug/ml) were significantly higher than in controls (34 mug/ml and 18 mug/ml respectively). Duodenal ulcer patients had normal or moderately raised values. The levels in gastric ulcer patients were as high as those which have been found experimentally to cause severe damage to the gastric mucosal barrier, and it is concluded that lysolecithin may be as important, or more important, than bile salts in the destruction of the gastric mucosal barrier and therefore in the aetiology of gastric ulcer.
溶血卵磷脂是在胰液和胆汁于十二指肠混合时形成的。已对胃溃疡和十二指肠溃疡患者夜间胃液的间歇性样本以及正常对照者的夜间胃液进行了溶血卵磷脂浓度测定。在胃溃疡患者中，峰值浓度的平均值（444微克/毫升）和所有样本中浓度的平均值（199微克/毫升）显著高于对照组（分别为34微克/毫升和18微克/毫升）。十二指肠溃疡患者的值正常或略有升高。胃溃疡患者体内的水平高达实验发现会对胃黏膜屏障造成严重损害的水平，由此得出结论，溶血卵磷脂在破坏胃黏膜屏障以及胃溃疡病因学方面可能与胆盐同等重要或更为重要。
