Roberts T L, Futrell J W, Sande M A
Ann Surg. 1979 Apr;189(4):395-403.
The concentration of antibiotic in peripheral lymph reflects the tissue levels. Following microsurgical cannulation of the right lymphatic duct in 28 healthy rabbits, either penicillin-G, nafcillin, erythromycin, or cefazolin was given intramuscularly, and lymph and serum samples obtained at frequent intervals. Penicillin or nafcillin was administered to 14 additional rabbits with cellulitis of the right upper extremity. A serum sample drawn between one and two hours after an intramuscular injection, in general, reflects the peak lymph antibiotic concentration and hence the peak tissue concentration of the drug. After two hours the lymph level remains equal to or greater than the simultaneous serum level. The presence of inflammation did not alter the peak antibiotic levels. However, nafcillin required longer for equilibration in the inflamed state than in the uninflamed state, whereas penicillin-G equilibrated more rapidly in the presence of inflammation.
外周淋巴中抗生素的浓度反映了组织中的水平。在对28只健康兔子的右淋巴管进行显微外科插管后，分别肌肉注射青霉素G、萘夫西林、红霉素或头孢唑林，并频繁采集淋巴液和血清样本。另外给14只患有右上肢蜂窝织炎的兔子注射青霉素或萘夫西林。一般来说，肌肉注射后一到两小时采集的血清样本反映了淋巴中抗生素的峰值浓度，因此也反映了药物在组织中的峰值浓度。两小时后，淋巴液水平保持等于或高于同时期的血清水平。炎症的存在并未改变抗生素的峰值水平。然而，萘夫西林在炎症状态下达到平衡所需的时间比在非炎症状态下更长，而青霉素G在有炎症时达到平衡的速度更快。
