Chisholm G D, Waterworth P M, Calnan J S, Garrod L P
Br Med J. 1973 Mar 10;1(5853):569-73. doi: 10.1136/bmj.1.5853.569.
The concentration of antibacterial agents in the interstitial tissue fluid has been studied in an experimental model using implanted perforated Silastic capsules (tissue cages). Tissue fluid concentrations were always lower than the initial peak concentration in the serum, but for those drugs that were more slowly excreted the tissue fluid was similar to the serum concentration after six hours. In contrast the concentration in the tissue fluid for those drugs that are excreted rapidly was unpredictable, being either negligible or maintained at concentrations significantly better than in the serum. There was no evidence of accumulation in tissue fluid with regular dosage. These results indicate that the tissues may never be exposed to an adequate concentration of some antibacterial agents. This may be of clinical importance in tissue infections. Antibiotics which are rapidly excreted should be given in large enough doses and often enough for adequate blood levels to be maintained, so allowing equilibrium with tissue fluid to be achieved.
在一个使用植入多孔硅橡胶胶囊（组织笼）的实验模型中，研究了抗菌剂在间质组织液中的浓度。组织液浓度始终低于血清中的初始峰值浓度，但对于排泄较慢的那些药物，六小时后组织液浓度与血清浓度相似。相比之下，对于快速排泄的那些药物，其在组织液中的浓度不可预测，要么可忽略不计，要么维持在明显高于血清的浓度水平。常规给药时，没有证据表明组织液中有蓄积现象。这些结果表明，某些抗菌剂的组织浓度可能永远达不到足够水平。这在组织感染中可能具有临床重要性。对于快速排泄的抗生素，应给予足够大的剂量并足够频繁给药，以维持足够的血药浓度，从而实现与组织液的平衡。
