Donchenko G V, Kruglikova A A, Zabarnaia E N
Ukr Biokhim Zh (1978). 1979 Nov-Dec;51(6):676-9.
Enzymic activity of tyrosine aminotransferase is unchanged in subcellular fractions of the liver tissue of control, E-hypovitaminotic rats and of the same animals subjected to a single vitamin E administration. Enzymic activity of phenyl alanine-4-hydroxylase in the supernatant fraction determined in the incubation medium without biopterin in animals with E-hypovitaminosis is 39% lower than in the control rats. The coefficient of phenyl alanine-4-hydroxylase activation with biopterin in vitro in E-hypovitaminotic animals is thrice as high as that in the control rats. A single vitamin E administration produces a 1.8-fold decrease in the activation coefficient. The data obtained give reason to suggest the possible influence to vitamin E on the biopterin level in the liver.
在对照组、维生素E缺乏大鼠以及单次给予维生素E的相同动物的肝脏组织亚细胞组分中，酪氨酸转氨酶的酶活性未发生变化。在无生物蝶呤的孵育培养基中测定的维生素E缺乏动物上清液组分中苯丙氨酸-4-羟化酶的酶活性比对照大鼠低39%。维生素E缺乏动物体外生物蝶呤对苯丙氨酸-4-羟化酶的激活系数是对照大鼠的三倍。单次给予维生素E可使激活系数降低1.8倍。所得数据表明维生素E可能对肝脏中生物蝶呤水平有影响。
