Wolff F, Meier U, Bolte A
Z Geburtshilfe Perinatol. 1979 Oct;183(5):343-7.
Lungs edemas in five pregnant women under i.v. tocolytic treatment with betaadrenergic drugs between the 28.--33. week of gestation are reported. Additionally, in all cases Betamethasone was given to prevent fetal lungs dysmaturity. Within less than 72 hours the occurrence of lungs edema was observed when both drugs were given simultaneously. These findings are in agreement with those of other authors, who observed similar symptoms in as well clinically healthy pregnant women under the same therapy. As the underlying pathomechanism the coincidence of the following factors are discussed: 1. An increased pressure in the pulmonary circulatory system as found in current, not yet published heart catheter investigations. 2. A reduced colloidosmotic pressure caused by Beta-methasone.
报告了5名在妊娠28至33周期间接受静脉注射β-肾上腺素能药物进行保胎治疗的孕妇发生肺水肿的情况。此外，所有病例均给予倍他米松以预防胎儿肺发育不全。当两种药物同时使用时，在不到72小时内观察到肺水肿的发生。这些发现与其他作者的研究结果一致，他们在相同治疗下的临床健康孕妇中也观察到了类似症状。作为潜在的发病机制，讨论了以下因素的巧合：1. 在目前尚未发表的心脏导管检查中发现肺循环系统压力升高。2. 倍他米松导致胶体渗透压降低。
