Daley M L, Swank R L, Ellison C M
Arch Neurol. 1979 May;36(5):292-5. doi: 10.1001/archneur.1979.00500410070010.
Patients with multiple sclerosis (MS) have been shown to have a measurable deterioration in the ability to perceive temporal variations of light. Compared to the traditional critical flicker fusion (CFF) measure, a modified flicker fusion test showed an improved sensitivity for denoting neurological deficit in temporal vision. One hundred twenty-two patients with MS were examined. The traditional CFF test exhibited abnormalities in 48%; the modified test exhibited abnormalities in 78% of the same patients. These results appear to be independent of whether or not the demyelinating disease clinically involved the visual system. Also, the percentage of abnormalities demonstrated by combining both techniques was unexpectedly high (60% to 80%) in patients with minimal evidence of neurological involvement.
多发性硬化症（MS）患者在感知光的时间变化能力方面已被证明存在可测量的退化。与传统的临界闪烁融合（CFF）测量方法相比，改良闪烁融合测试在检测时间视觉方面的神经功能缺损时显示出更高的灵敏度。对122例MS患者进行了检查。传统的CFF测试显示48%的患者存在异常；改良测试在相同患者中显示78%存在异常。这些结果似乎与脱髓鞘疾病在临床上是否累及视觉系统无关。此外，在神经受累证据最少的患者中，两种技术结合显示的异常百分比出人意料地高（60%至80%）。
