Schwartzenberg T, Vancea P P, Dobrescu G
J Fr Ophtalmol. 1979 Feb;2(2):85-94.
Based on a study of 34 cases, the authors make therapeutical and diagnostical references concerning the epibulbar malignant tumours. These were met with a frequency of 10% of the total amount of the malignant tumours of the visual apparatus. The most frequent setting were at the level of the bulbar conjunctiva and of the sclero-corneal limb, especially in front of the opening of the palpebral slit and in the temporal area. The histological examination of the tumours pointed out the following morphological types; epitheliomas (61%), especially spino-cellular, malignant melanomas (32%) and sarcomas (6%). The therapeutical attitude was the surgical one -- the accurate extirpation -- in the limited tumours, followed by radiotherapy when neoplasic lesions were found at the limit of section. In the invaded tumours, the exenteration of the orbit was performed followed by radiotherapy. On the terms of such a therapeutical conduct, the distant prognosis proved to be dependent on two factors: a. The early diagnosis, that is the stage of the therapeutical action. It is insisted upon the importance of the signs of malignization of some benign tumors: papillomas or naevi. b. The nature and origin of the tumour: the secondary tumours are more severe from the beginning.
基于对34例病例的研究，作者就眼球表面恶性肿瘤提出了治疗和诊断参考。这些肿瘤在视觉器官恶性肿瘤总数中所占比例为10%。最常见的发病部位是球结膜和巩膜角膜缘水平，尤其是睑裂开口前方和颞侧区域。肿瘤的组织学检查显示出以下形态学类型：上皮瘤（61%），尤其是棘细胞癌、恶性黑色素瘤（32%）和肉瘤（6%）。治疗方法是手术治疗——精确切除——对于局限性肿瘤，若在手术切缘发现肿瘤病变，则术后进行放疗。对于侵犯性肿瘤，进行眼眶内容剜除术，术后进行放疗。按照这样的治疗方式，远期预后取决于两个因素：a. 早期诊断，即治疗行动的阶段。强调了一些良性肿瘤（乳头状瘤或痣）恶变迹象的重要性。b. 肿瘤的性质和起源：继发性肿瘤从一开始就更为严重。
