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1
The effect of starvation on the rate of protein synthesis in rat liver and small intestine.饥饿对大鼠肝脏和小肠蛋白质合成速率的影响。
Biochem J. 1979 Feb 15;178(2):373-9. doi: 10.1042/bj1780373.
2
Protein synthesis in liver and small intestine in protein deprivation and diabetes.蛋白质缺乏和糖尿病状态下肝脏及小肠中的蛋白质合成
Am J Physiol. 1981 Sep;241(3):E238-45. doi: 10.1152/ajpendo.1981.241.3.E238.
3
Failure of leucine to stimulate protein synthesis in vivo.亮氨酸在体内无法刺激蛋白质合成。
Biochem J. 1982 Jun 15;204(3):831-8. doi: 10.1042/bj2040831.
4
Ketoisocaproate contamination errors in protein synthesis determinations using L[1-14C]leucine.使用L-[1-¹⁴C]亮氨酸进行蛋白质合成测定时的酮异己酸污染误差。
J Biochem Biophys Methods. 1993 Aug;27(1):57-63. doi: 10.1016/0165-022x(93)90068-y.
5
Protein synthesis in rat small intestine.大鼠小肠中的蛋白质合成。
Proc Nutr Soc. 1978 Sep;37(2):28A.
6
Isolation of microvilli fraction from jejunal mucosa and in vivo incorporation of 14C-leucine into microvilli and total homogenate protein of suckling rats.从空肠黏膜中分离微绒毛组分以及14C-亮氨酸在乳鼠微绒毛和全匀浆蛋白中的体内掺入。
Biol Neonate. 1974;24(3):230-43. doi: 10.1159/000240654.
7
Stimulation of jejunal mucosal protein synthesis by luminal glucose. Effects with luminal and vascular leucine in fed and fasted rats.肠腔葡萄糖对空肠黏膜蛋白质合成的刺激作用。喂食和禁食大鼠中肠腔和血管亮氨酸的影响。
Gastroenterology. 1989 Mar;96(3):935-7.
8
The diurnal response of muscle and liver protein synthesis in vivo in meal-fed rats.进食大鼠体内肌肉和肝脏蛋白质合成的昼夜反应。
Biochem J. 1973 Dec;136(4):935-45. doi: 10.1042/bj1360935.
9
Protein starvation and the small intestine. 3. Incorporation of orally and intraperitoneally administered 1-leucine 4,5-3H into intestinal mucosal protein of protein-deprived rats.蛋白质饥饿与小肠。3. 蛋白质缺乏大鼠经口和腹腔注射4,5-³H标记的L-亮氨酸后其在肠黏膜蛋白中的掺入情况。
J Clin Invest. 1969 Jul;48(7):1224-9. doi: 10.1172/JCI106086.
10
The influence of the gut microflora on protein synthesis in liver and jejunal mucosa in chicks.肠道微生物群对雏鸡肝脏和空肠黏膜蛋白质合成的影响。
Br J Nutr. 1983 May;49(3):453-62. doi: 10.1079/bjn19830054.

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Amino Acids in Beef Cattle Nutrition and Production.氨基酸在肉牛营养与生产中的应用
Adv Exp Med Biol. 2021;1285:29-42. doi: 10.1007/978-3-030-54462-1_3.
2
Oral exposure of pigs to the mycotoxin deoxynivalenol does not modulate the hepatic albumin synthesis during a LPS-induced acute-phase reaction.猪经口暴露于霉菌毒素脱氧雪腐镰刀菌烯醇并不会调节脂多糖诱导的急性相反应期间肝脏白蛋白的合成。
Innate Immun. 2020 Nov;26(8):716-732. doi: 10.1177/1753425920937778. Epub 2020 Jul 23.
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Phenylbutyrate exerts adverse effects on liver regeneration and amino acid concentrations in partially hepatectomized rats.苯丁酸盐对部分肝切除大鼠的肝脏再生和氨基酸浓度产生不利影响。
Int J Exp Pathol. 2016 Jun;97(3):278-84. doi: 10.1111/iep.12190. Epub 2016 Jul 6.
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Alterations in protein and amino acid metabolism in rats fed a branched-chain amino acid- or leucine-enriched diet during postprandial and postabsorptive states.在餐后和吸收后状态下，给大鼠喂食富含支链氨基酸或亮氨酸的饮食后，其蛋白质和氨基酸代谢的变化。
Nutr Metab (Lond). 2016 Feb 11;13:12. doi: 10.1186/s12986-016-0072-3. eCollection 2016.
5
Flooding-dose of various amino acids for measurement of whole-body protein synthesis in the rat. flooding-dose 法测定大鼠整体蛋白质合成的各种氨基酸。
Amino Acids. 1991 Feb;1(1):17-27. doi: 10.1007/BF00808087.
6
Amino acid flooding doses for measuring rates of protein synthesis.氨基酸驱油剂量测定蛋白质合成速率。
Amino Acids. 1993 Feb;4(1-2):5-19. doi: 10.1007/BF00805797.
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Source of amino acids for tRNA acylation in growing chicks.在生长雏鸡中，tRNA 酰化的氨基酸来源。
Amino Acids. 1994 Oct;7(3):267-78. doi: 10.1007/BF00807702.
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Determination of steady-state protein breakdown rate in vivo by the disappearance of protein-bound tracer-labeled amino acids: a method applicable in humans.用蛋白结合示踪标记氨基酸的消失来测定体内稳定态蛋白质降解率：一种适用于人类的方法。
Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E895-907. doi: 10.1152/ajpendo.00579.2012. Epub 2013 Feb 19.
9
A role for Drosophila dFoxO and dFoxO 5'UTR internal ribosomal entry sites during fasting.果蝇 dFoxO 和 dFoxO 5'UTR 内部核糖体进入位点在禁食期间的作用。
PLoS One. 2010 Jul 9;5(7):e11521. doi: 10.1371/journal.pone.0011521.
10
Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise.运动后人髌骨肌腱和股四头肌中胶原蛋白与肌肉蛋白的协同合成
J Physiol. 2005 Sep 15;567(Pt 3):1021-33. doi: 10.1113/jphysiol.2005.093690. Epub 2005 Jul 7.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
POSSIBLE SYNTHESIS OF POLYRIBONUCLEOTIDES OF KNOWN BASE-TRIPLET SEQUENCES.已知碱基三联体序列的多核糖核苷酸的可能合成
Nature. 1965 Apr 3;206:93. doi: 10.1038/206093b0.
3
The effect of starvation on epithelial renewal in the rat duodenum.饥饿对大鼠十二指肠上皮更新的影响。
Exp Cell Res. 1958 Feb;14(1):175-81. doi: 10.1016/0014-4827(58)90224-6.
4
Inhibition of intestinal epithelial cell renewal and migration induced by starvation.饥饿诱导的肠上皮细胞更新和迁移的抑制
Am J Physiol. 1963 Nov;205(5):868-72. doi: 10.1152/ajplegacy.1963.205.5.868.
5
Protein starvation and the small intestine. 3. Incorporation of orally and intraperitoneally administered 1-leucine 4,5-3H into intestinal mucosal protein of protein-deprived rats.蛋白质饥饿与小肠。3. 蛋白质缺乏大鼠经口和腹腔注射4,5-³H标记的L-亮氨酸后其在肠黏膜蛋白中的掺入情况。
J Clin Invest. 1969 Jul;48(7):1224-9. doi: 10.1172/JCI106086.
6
The effect of low protein diets on the turn-over rates of serums, liver and muscle proteins in the rat, measured by continuous infusion of L-[14C]lysine.通过持续输注L-[14C]赖氨酸测定低蛋白饮食对大鼠血清、肝脏和肌肉蛋白质周转率的影响。
Clin Sci. 1968 Oct;35(2):287-305.
7
Studies in vitro on free amino acid pools and protein synthesis in rat jejunum.大鼠空肠游离氨基酸库及蛋白质合成的体外研究。
Eur J Clin Invest. 1971 Jan;1(4):211-5.
8
Control of protein synthesis in mammalian tissues through changes in ribosome activity.通过核糖体活性的变化来控制哺乳动物组织中的蛋白质合成。
J Biol Chem. 1971 Jan 25;246(2):436-46.
9
Effect of fasting versus feeding on the rat small intestine. Morphological, biochemical, and functional differences.禁食与进食对大鼠小肠的影响。形态学、生物化学及功能差异。
Gastroenterology. 1970 Aug;59(2):214-21.
10
The assessment of intestinal protein turnover in the rat by three techniques.采用三种技术对大鼠肠道蛋白质周转进行评估。
Gut. 1971 Jun;12(6):495-6.

饥饿对大鼠肝脏和小肠蛋白质合成速率的影响。

The effect of starvation on the rate of protein synthesis in rat liver and small intestine.

作者信息

McNurlan M A, Tomkins A M, Garlick P J

出版信息

Biochem J. 1979 Feb 15;178(2):373-9. doi: 10.1042/bj1780373.

DOI:10.1042/bj1780373
PMID:444219
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1186525/
Abstract
  1. A method is described that allows for measurement of protein synthesis in liver and intestine in the rat. By injecting a massive amount of [14C]leucine (100 mumol/100 g body wt.) an attempt has been made to over come problems of precursor specific radioactivity and problems arising from the breakdown of labelled protein that are encountered when tracer amounts of amino acids are used. 2. Starvation for 2 days resulted in decline in the rate of total liver protein synthesis from 87%/day to 62%/day. 3. In jejunal mucosa the rate of protein synthesis was 136%/day. This declined to 105%/day after 2 days of starvation.
摘要
  1. 本文描述了一种可用于测量大鼠肝脏和肠道中蛋白质合成的方法。通过注射大量的[14C]亮氨酸（100微摩尔/100克体重），试图克服使用微量氨基酸作为示踪剂时遇到的前体比放射性问题以及标记蛋白质分解所产生的问题。2. 饥饿2天导致肝脏总蛋白质合成速率从每天87%降至每天62%。3. 在空肠黏膜中，蛋白质合成速率为每天136%。饥饿2天后，该速率降至每天105%。