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针灸与胃酸研究。

Acupuncture and gastric acid studies.

作者信息

Sodipo J O, Falaiye J M

出版信息

Am J Chin Med. 1979 Winter;7(4):356-61. doi: 10.1142/s0192415x79000337.

DOI:10.1142/s0192415x79000337
PMID:44432
Abstract

The effects of therapeutic acupuncture on gastric acid secretion on pain relief in chronic duodenal ulcer patients were studied. Ten adult Nigerian patients with clinical, endoscopic as well as radiological evidence of duodenal ulcer constituted the "Ulcer Group." Four other patients who gave history of dyspepsia formed the "Dyspeptic Group." Pentagastrin stimulation test was performed on all subjects pre- and post-acupuncture therapy. The classical Chinese acupuncture loci were employed. The mean Basal Acid Output (BAO) in the duodenal ulcer group was markedly reduced from 4.04 +/- 1.01 mMols/hour to 1.05 +/- 2.5 mMols/hour. The mean Maximal Acid Output (MAO) was lowered from 34.72 +/- 13.81 mMols/hour to 15.34 +/- 4.01 mMols/hour. The difference was statistically significant (P less than 0.001). It is more probable, therefore, that the relief of pain is attributable to the therapeutic inhibition of gastric hyperacidity in our patients. Thus, though pain relief has been previously demonstrated in response to acupuncture, the results of this investigation have gone further to show that acupunture achieves symptomatic relief through therapeutic gastric depression in duodenal ulcer patients.

摘要

研究了治疗性针灸对慢性十二指肠溃疡患者胃酸分泌及疼痛缓解的影响。十名成年尼日利亚患者,具备十二指肠溃疡的临床、内镜及放射学证据,组成了“溃疡组”。另外四名有消化不良病史的患者组成了“消化不良组”。对所有受试者在针灸治疗前后进行了五肽胃泌素刺激试验。采用了经典的中国针灸穴位。十二指肠溃疡组的平均基础酸排量(BAO)从4.04±1.01毫摩尔/小时显著降至1.05±2.5毫摩尔/小时。平均最大酸排量(MAO)从34.72±13.81毫摩尔/小时降至15.34±4.01毫摩尔/小时。差异具有统计学意义(P<0.001)。因此,更有可能的是,疼痛缓解归因于对我们患者胃酸过多的治疗性抑制。所以,尽管先前已证明针灸可缓解疼痛,但本研究结果进一步表明,针灸通过治疗性抑制十二指肠溃疡患者的胃酸分泌来实现症状缓解。

相似文献

1
Acupuncture and gastric acid studies.针灸与胃酸研究。
Am J Chin Med. 1979 Winter;7(4):356-61. doi: 10.1142/s0192415x79000337.
2
A critical analysis of the gastric secretory response of patients with duodenal ulcer in dependence of their age and duration of complaints.对十二指肠溃疡患者的胃分泌反应依其年龄和主诉持续时间的批判性分析。
Acta Med Acad Sci Hung. 1981;38(2):117-28.
3
Histamine and insulin dose-response studies of gastric secretion in Indian control subjects and patients with duodenal ulcer in the Ganges delta.印度恒河三角洲地区健康对照人群及十二指肠溃疡患者胃分泌的组胺和胰岛素剂量反应研究。
Gut. 1978 Oct;19(10):878-85. doi: 10.1136/gut.19.10.878.
4
Comparison of maximal acid output and gastrin response to meals in Chinese and Scottish normal and duodenal ulcer subjects.中国和苏格兰正常人与十二指肠溃疡患者的最大酸排量及进餐时胃泌素反应的比较。
Gut. 1980 Apr;21(4):324-8. doi: 10.1136/gut.21.4.324.
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Observations on gastric acid output by a three-hour histamine infusion test using maximal doses on patients with duodenal ulcer and in normal controls.对十二指肠溃疡患者和正常对照者使用最大剂量组胺进行三小时输注试验时胃酸分泌情况的观察。
Gut. 1970 Dec;11(12):994-7. doi: 10.1136/gut.11.12.994.
6
The relation between gastric acid secretion and body habitus, blood groups, smoking, and the subsequent development of dyspepsia and duodenal ulcer.胃酸分泌与身体体型、血型、吸烟以及随后消化不良和十二指肠溃疡的发生之间的关系。
Gut. 1973 Feb;14(2):107-12. doi: 10.1136/gut.14.2.107.
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Gastric acid secretion in Chinese with particular reference to the dose of histamine required for maximal stimulation.中国人胃酸分泌情况,特别涉及最大刺激所需组胺剂量。
Gut. 1970 Nov;11(11):955-61. doi: 10.1136/gut.11.11.955.
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Maximum acid output in duodenal ulcer patients with different length of history and controls without dyspepsia.不同病史时长的十二指肠溃疡患者及无消化不良症状的对照组的最大胃酸分泌量。
Scand J Gastroenterol. 1977;12(8):957-62. doi: 10.3109/00365527709181356.
9
Effect of pentagastrin on histamine output from the stomach in patients with duodenal ulcer.五肽胃泌素对十二指肠溃疡患者胃组胺分泌量的影响。
Gut. 1981 Nov;22(11):916-22. doi: 10.1136/gut.22.11.916.
10
Serum gastrin response to food stimulation and gastric acid secretion in male patients with duodenal ulcer.男性十二指肠溃疡患者血清胃泌素对食物刺激的反应及胃酸分泌情况
Scand J Gastroenterol. 1975;10(2):187-91.

引用本文的文献

1
Potential Mechanisms of Acupuncture for Functional Dyspepsia Based on Pathophysiology.基于病理生理学的针刺治疗功能性消化不良的潜在机制
Front Neurosci. 2022 Jan 25;15:781215. doi: 10.3389/fnins.2021.781215. eCollection 2021.
2
Acupuncture and regulation of gastrointestinal function.针灸与胃肠功能调节
World J Gastroenterol. 2015 Jul 21;21(27):8304-13. doi: 10.3748/wjg.v21.i27.8304.
3
Mechanism of reflex regulation of the gastroduodenal function by acupuncture.针刺调节胃十二指肠功能的反射机制。
Evid Based Complement Alternat Med. 2008 Sep;5(3):251-6. doi: 10.1093/ecam/nem077.
4
Electroacupuncture accelerates solid gastric emptying and improves dyspeptic symptoms in patients with functional dyspepsia.电针可加速功能性消化不良患者的胃固体排空并改善消化不良症状。
Dig Dis Sci. 2006 Dec;51(12):2154-9. doi: 10.1007/s10620-006-9412-x. Epub 2006 Nov 3.
5
Acupuncture inhibits vagal gastric acid secretion stimulated by sham feeding in healthy subjects.针刺可抑制健康受试者假饲刺激引起的迷走神经介导的胃酸分泌。
Gut. 1994 Aug;35(8):1026-9. doi: 10.1136/gut.35.8.1026.
6
Effect of acupuncture on gastric acid secretion in healthy male volunteers.针刺对健康男性志愿者胃酸分泌的影响。
Dig Dis Sci. 1992 Oct;37(10):1576-82. doi: 10.1007/BF01296505.