卡介苗和短小棒状杆菌免疫疗法对人体肝脏药物羟化作用无效。
Lack of effect of immunotherapy with BCG and Corynebacterium parvum on hepatic drug hydroxylation in man.
作者信息
Wan H H, Thatcher N, Mullen P W, Smith G N, Wilkinson P M
出版信息
Br J Cancer. 1979 Apr;39(4):441-4. doi: 10.1038/bjc.1979.78.
Abstract
Serial serum diphenylhydantoin and urinary 5-(p-hydroxphenyl)-5-phenylhydantoin concentrations were determined in 8 patients with malignant disease and 4 healthy volunteers on 2 separate occasions after an oral dose of diphenylhydantoin (500 mg). No significant difference was observed between metabolism before and 10 days after immunization with BCG or Corynebacterium parvum. Volunteers without intervening immunization similarly showed no difference.
摘要
在8例恶性疾病患者和4名健康志愿者口服苯妥英钠（500毫克）后的2个不同时间点，测定了其血清苯妥英钠和尿中5 -（对羟基苯基）- 5 - 苯基乙内酰脲的浓度。在用卡介苗或短小棒状杆菌免疫前和免疫后10天之间，未观察到代谢方面的显著差异。未进行中间免疫的志愿者也同样未显示出差异。
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本文引用的文献
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Rapid determination of diphenylhydantoin in blood plasma by gas-liquid chromatography.气液色谱法快速测定血浆中的苯妥英
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The rate of decline of diphenylhydantoin in human plasma.人体血浆中苯妥英的下降速率。
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Explanation of dose-dependent decline of diphenylhydantoin plasma levels by fitting to the integrated form of the Michaelis-Menten equation.通过拟合米氏方程的积分形式来解释苯妥英血浆水平的剂量依赖性下降。
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Effect of diphenylhydantoin on hepatic drug hydroxylation.苯妥英对肝脏药物羟化作用的影响。
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Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin).接受苯妥英钠（二苯乙内酰脲钠）治疗患者的免疫功能抑制
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Comparative drug elimination in man-diphenylhydantoin and amobarbital.人体内苯妥英钠和异戊巴比妥的药物消除比较
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