卡介苗和短小棒状杆菌免疫疗法对人体肝脏药物羟化作用无效。
Lack of effect of immunotherapy with BCG and Corynebacterium parvum on hepatic drug hydroxylation in man.
作者信息
Wan H H, Thatcher N, Mullen P W, Smith G N, Wilkinson P M
出版信息
Br J Cancer. 1979 Apr;39(4):441-4. doi: 10.1038/bjc.1979.78.
Abstract
Serial serum diphenylhydantoin and urinary 5-(p-hydroxphenyl)-5-phenylhydantoin concentrations were determined in 8 patients with malignant disease and 4 healthy volunteers on 2 separate occasions after an oral dose of diphenylhydantoin (500 mg). No significant difference was observed between metabolism before and 10 days after immunization with BCG or Corynebacterium parvum. Volunteers without intervening immunization similarly showed no difference.
摘要
在8例恶性疾病患者和4名健康志愿者口服苯妥英钠（500毫克）后的2个不同时间点，测定了其血清苯妥英钠和尿中5 -（对羟基苯基）- 5 - 苯基乙内酰脲的浓度。在用卡介苗或短小棒状杆菌免疫前和免疫后10天之间，未观察到代谢方面的显著差异。未进行中间免疫的志愿者也同样未显示出差异。
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本文引用的文献
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Rapid determination of diphenylhydantoin in blood plasma by gas-liquid chromatography.气液色谱法快速测定血浆中的苯妥英
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